Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 13/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7979562 | 0.83 | MAPT (0.50) | MAPTTP53THRBSMN1; SMN2MEN1 | |
| SCHEMBL6293655 | 0.78 | ROCK2 (0.61) | MAPTTP53THRBSMN1; SMN2MEN1 | |
| SCHEMBL8023041 | 0.78 | MAPT (0.48) | MAPTTP53THRBSMN1; SMN2MEN1 | |
| SCHEMBL7801373 | 0.77 | ROCK2 (0.55) | MAPTTP53THRBSMN1; SMN2MEN1 | |
| SCHEMBL7660377 | 0.76 | MAPT (0.52) | MAPTTP53THRBSMN1; SMN2MEN1 | |
| SCHEMBL6294900 | 0.75 | ABCB1 (0.54) | MAPTTP53THRBSMN1; SMN2MEN1 | |
| SCHEMBL7989876 | 0.75 | MAPT (0.47) | MAPTTP53THRBSMN1; SMN2MEN1 | |
| SCHEMBL6293557 | 0.75 | NPC1 (0.50) | MAPTTP53THRBSMN1; SMN2MEN1 | |
| SCHEMBL6293579 | 0.75 | ROCK2 (0.53) | MAPTTP53THRBSMN1; SMN2MEN1 | |
| SCHEMBL7012602 | 0.75 | MAPT (0.49) | MAPTTP53THRBSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102769-B1 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2003-04-16 | — | — | EP | claimed |
| EP-1102769-A2 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2001-05-30 | — | — | EP | claimed |
| WO-2000008020-A2 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-02-17 | — | — | WO | claimed |
| EP-1102769-B1 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2003-04-16 | — | — | EP | disclosed |
| EP-1102769-A2 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000008020-A2 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-02-17 | — | — | WO | disclosed |