SCHEMBL7979562

SCHEMBL7979562

COc1ccc(C(=O)Nc2ccc3c(c2)C(C)(C)N(C)CC3)cc1C(F)(F)F

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.50
TP53 P04637 1/20 0.50
THRB P10828 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
KDM4E B2RXH2 1/20 0.49
MEN1 O00255 1/20 0.49
CYP2D6 P10635 1/20 0.49
CYP2C9 P11712 1/20 0.49
CYP2C19 P33261 1/20 0.49
HTT P42858 1/20 0.49
KMT2A Q03164 1/20 0.49
BRAF P15056 8/20 0.48
RAF1 P04049 1/20 0.48
ROCK2 O75116 2/20 0.47
CYP3A4 P08684 1/20 0.46
ABCB1 P08183 1/20 0.46
ABCG2 Q9UNQ0 1/20 0.46
NPC1 O15118 1/20 0.45
POLB P06746 1/20 0.45
RAB9A P51151 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7654954 0.89 MAPT (0.48) MAPTTP53THRBSMN1; SMN2KDM4E
Hydrochloric Acid SCHEMBL7651474 0.88 MAPT (0.47) MAPTTP53THRBSMN1; SMN2KDM4E
SCHEMBL7653638 0.87 BRAF (0.47) MAPTTP53THRBSMN1; SMN2KDM4E
SCHEMBL7651710 0.86 MAPT (0.44) MAPTTP53THRBSMN1; SMN2KDM4E
SCHEMBL7656801 0.86 BRAF (0.44) MAPTTP53THRBSMN1; SMN2KDM4E
Hydrochloric Acid SCHEMBL7662250 0.86 BRAF (0.46) MAPTTP53THRBSMN1; SMN2KDM4E
SCHEMBL7659513 0.84 BRAF (0.43) MAPTTP53THRBSMN1; SMN2KDM4E
SCHEMBL7008491 0.83 MAPT (0.47) MAPTTP53THRBSMN1; SMN2KDM4E
SCHEMBL6293655 0.83 ROCK2 (0.61) MAPTTP53THRBSMN1; SMN2KDM4E
SCHEMBL7989876 0.82 MAPT (0.47) MAPTTP53THRBSMN1; SMN2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6277861-B1 FOR TREATMENT AND PROPHYLAXIS OF NERVOUS SYSTEM DISORDERS, PSYCHOLOGICAL DISORDERS, MUSCULAR DISORDERS, DRUG ADDICTION WITHDRAWAL, PAIN SMITHKLINE BEECHAM, P.L.C. (GB) 2001-08-21 US claimed
US-6277861-B1 FOR TREATMENT AND PROPHYLAXIS OF NERVOUS SYSTEM DISORDERS, PSYCHOLOGICAL DISORDERS, MUSCULAR DISORDERS, DRUG ADDICTION WITHDRAWAL, PAIN SMITHKLINE BEECHAM, P.L.C. (GB) 2001-08-21 US disclosed