Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F | P30939 | 19/20 | 0.52 |
| ▸ | HTR1D | P28221 | 11/20 | 0.51 |
| ▸ | HTR1B | P28222 | 10/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 8/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | HTR1E | P28566 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7007720 | 0.82 | HTR1F (0.61) | HTR1FHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL7008182 | 0.82 | HTR1F (0.60) | HTR1FHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL30909165 | 0.81 | HTR1F (0.62) | HTR1FHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL7013343 | 0.81 | HTR1F (0.62) | HTR1FHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL30909044 | 0.81 | HTR1F (0.66) | HTR1FHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL7012776 | 0.78 | OPRM1 (0.58) | HTR1FHTR1DHTR1BOPRM1OPRK1 | |
| SCHEMBL30908848 | 0.78 | OPRM1 (0.58) | HTR1FHTR1DHTR1BOPRM1OPRK1 | |
| SCHEMBL7010188 | 0.78 | HTR1F (0.65) | HTR1FHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL7012228 | 0.77 | HTR1F (0.55) | HTR1FOPRM1OPRK1HTR1AHTR2A | |
| SCHEMBL7004931 | 0.74 | HTR1F (0.71) | HTR1FHTR1DHTR1BHTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024073845-A1 | METHODS AND PHARMACOLOGICAL AGENTS FOR INCREASING EXPANSION, ENGRAFTMENT OR IMMUNE OUTPUT OF HUMAN HEMATOPOIETIC STEM CELLS IN TRANSPLANTATION AND DISEASE SETTINGS | VALORISATION HSJ, LIMITED PARTNERSHIP (CA) | 2024-04-11 | — | — | WO | disclosed |
| EP-0916670-B1 | Pyrrolo-(3,2-b) pyridines and their use as 5-HT1F agonists | LILLY CO ELI (US) | 2003-05-14 | — | — | EP | disclosed |
| EP-0916670-A2 | Pyrrolo-(3,2-b) pyridines and their use as 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1999-05-19 | — | — | EP | disclosed |