Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.73 |
| ▸ | POLB | P06746 | 1/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | IGF1R | P08069 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1627475 | 0.88 | ALDH1A1 (0.66) | ALDH1A1KMT2APOLBSMN1; SMN2HPGD | |
| SCHEMBL5621143 | 0.85 | ALDH1A1 (1.00) | ALDH1A1KMT2APOLBSMN1; SMN2HPGD | |
| SCHEMBL11652842 | 0.83 | HPGD (0.72) | ALDH1A1KMT2APOLBSMN1; SMN2HPGD | |
| SCHEMBL25258780 | 0.83 | SMN1; SMN2 (0.60) | ALDH1A1KMT2APOLBSMN1; SMN2HPGD | |
| SCHEMBL13982876 | 0.82 | ALDH1A1 (0.82) | ALDH1A1KMT2APOLBSMN1; SMN2HPGD | |
| SCHEMBL25294601 | 0.81 | SMN1; SMN2 (0.58) | ALDH1A1KMT2APOLBSMN1; SMN2HPGD | |
| SCHEMBL25258164 | 0.81 | SMN1; SMN2 (0.58) | ALDH1A1KMT2APOLBSMN1; SMN2HPGD | |
| SCHEMBL25295408 | 0.81 | SMN1; SMN2 (0.58) | ALDH1A1KMT2APOLBSMN1; SMN2HPGD | |
| SCHEMBL7253512 | 0.81 | ALDH1A1 (0.85) | ALDH1A1KMT2APOLBSMN1; SMN2HPGD | |
| SCHEMBL25253782 | 0.80 | SMN1; SMN2 (0.57) | ALDH1A1KMT2APOLBSMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733633-B1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-05-28 | — | — | EP | disclosed |
| US-5753664-A | ANTITUMOR AGENTS, PYRIMIDONES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-05-19 | — | — | US | disclosed |
| EP-0733633-A1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-09-25 | — | — | EP | disclosed |