Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23309745 | 0.69 | HPGD (0.66) | MEN1KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL21851971 | 0.67 | KMT2A (0.69) | MEN1KMT2AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL7439085 | 0.67 | MEN1 (0.61) | MEN1KMT2AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL14198603 | 0.67 | KMT2A (0.79) | MEN1KMT2AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL23273280 | 0.67 | ALOX15 (0.51) | MEN1KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL23273330 | 0.67 | ALOX15 (0.51) | MEN1KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL21761667 | 0.66 | HPGD (0.49) | MEN1KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL19359219 | 0.65 | TP53 (0.60) | KMT2AALDH1A1SMN1; SMN2KDM4ETSHR | |
| SCHEMBL1927731 | 0.65 | TP53 (0.60) | KMT2AALDH1A1SMN1; SMN2KDM4ETSHR | |
| SCHEMBL7837431 | 0.65 | HDAC8 (0.77) | MEN1KMT2AALDH1A1KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1278739-A1 | AMINO SUBSTITUTED DIBENZOTHIOPHENE DERIVATIVES FOR THE TREATMENT OF DISORDERS MEDIATED BY THE NP Y5 RECEPTOR | AstraZeneca AB (SE) | 2003-01-29 | — | — | EP | disclosed |
| WO-2001085714-A1 | AMINO SUBSTITUTED DIBENZOTHIOPHENE DERIVATIVES FOR THE TREATMENT OF DISORDERS MEDIATED BY THE NP Y5 RECEPTOR | ASTRAZENECA AB (SE) | 2001-11-15 | — | — | WO | disclosed |