Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | NPY1R | P25929 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17594976 | 0.90 | PIK3CA (0.54) | PIK3CASIRT2SIRT1LMNAKDM4E | |
| SCHEMBL7018463 | 0.78 | NPY1R (0.43) | PIK3CASIRT2SIRT1LMNANPY1R | |
| SCHEMBL28410092 | 0.76 | NPC1 (0.37) | SIRT2SIRT1KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL5214322 | 0.75 | PIK3CA (0.56) | PIK3CASIRT2SIRT1LMNAKDM4E | |
| SCHEMBL7016486 | 0.74 | MEN1 (0.51) | PIK3CALMNAKDM4EALDH1A1ALOX15 | |
| SCHEMBL862162 | 0.74 | CYP1A2 (0.50) | KDM4EALDH1A1L3MBTL1HPGDHSD17B10 | |
| SCHEMBL17595153 | 0.74 | CYP1A2 (0.47) | LMNAKDM4EALDH1A1L3MBTL1POLB | |
| SCHEMBL15328399 | 0.73 | CYP3A4 (0.58) | PIK3CASIRT2SIRT1LMNAKDM4E | |
| SCHEMBL15681613 | 0.73 | PIK3CA (0.51) | PIK3CASIRT2SIRT1LMNAKDM4E | |
| SCHEMBL20098275 | 0.73 | KDM4E (0.50) | PIK3CASIRT2SIRT1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165555-B1 | ARYL FUSED 2,4-DISUBSTITUTED PYRIDINES: NK3 RECEPTOR LIGANDS | NEUROGEN CORP (US) | 2003-07-16 | — | — | EP | claimed |
| EP-0889034-B1 | AMINOPYRIDINE DERIVATIVES | BANYU PHARMA CO LTD (JP) | 2003-09-17 | — | — | EP | disclosed |
| US-6011039-A | USEFUL AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS; TREATING HYPERPHAGIA, OBESITY OR DIABETES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2000-01-04 | — | — | US | disclosed |
| EP-0889034-A1 | AMINOPYRIDINE DERIVATIVES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1999-01-07 | — | — | EP | disclosed |