Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 3/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | HTR2B | P41595 | 2/20 | 0.40 |
| ▸ | CTSL | P07711 | 2/20 | 0.40 |
| ▸ | CTSB | P07858 | 2/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7008755 | 0.90 | CA1 (0.46) | KMOHDAC8LMNAATMCTSS | |
| SCHEMBL5796714 | 0.81 | MAPK1 (0.38) | LMNASMN1; SMN2ATMCTSSCTSL | |
| SCHEMBL6255179 | 0.80 | MAPK1 (0.38) | LMNASMN1; SMN2ATMCTSSCTSL | |
| SCHEMBL6257465 | 0.79 | MAPK1 (0.39) | LMNASMN1; SMN2ATMCTSSCTSL | |
| SCHEMBL6252719 | 0.79 | MAPK1 (0.39) | LMNASMN1; SMN2ATMCTSSCTSL | |
| SCHEMBL5050630 | 0.77 | HTR2A (0.53) | KMOP2RX7ATMHTR1AADRA2A | |
| SCHEMBL5636335 | 0.77 | HTR2A (0.53) | KMOP2RX7ATMHTR1AADRA2A | |
| SCHEMBL4845787 | 0.77 | PREP (0.46) | LMNAATMCTSSHTR1AADRA2A | |
| SCHEMBL6254005 | 0.77 | ATM (0.41) | LMNASMN1; SMN2ATMCTSSHTR2A | |
| SCHEMBL6250919 | 0.76 | ATM (0.41) | HDAC8LMNASMN1; SMN2ATMCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268438-A1 | 6-HYDROXY-INDAZOLE DERIVATIVES FOR TREATING GLAUCOMA | Alcon, Inc (CH) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070702-A1 | 6-HYDROXY-INDAZOLE DERIVATIVES FOR TREATING GLAUCOMA | ALCON, INC. (CH) | 2001-09-27 | — | — | WO | disclosed |