Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 8/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | TOP2A | P11388 | 9/20 | 0.34 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.34 |
| ▸ | PIM1 | P11309 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7010691 | 0.92 | STAT3 (0.39) | TOP1ALDH1A1HTTSTAT3GSK3B | |
| SCHEMBL7008690 | 0.91 | TOP1 (0.38) | TOP1ALDH1A1HTTSTAT3GSK3B | |
| SCHEMBL20912614 | 0.89 | TOP1 (0.36) | TOP1ALDH1A1HTTSTAT3GSK3B | |
| SCHEMBL6576283 | 0.89 | TOP1 (0.43) | TOP1ALDH1A1HTTSTAT3GSK3B | |
| SCHEMBL7014048 | 0.84 | TOP1 (0.46) | TOP1ALDH1A1TOP2ATOP2BPIM1 | |
| SCHEMBL7005814 | 0.83 | TOP1 (0.40) | TOP1ALDH1A1HTTSTAT3GSK3B | |
| SCHEMBL6581471 | 0.83 | TOP2A (0.42) | TOP1ALDH1A1HTTSTAT3GSK3B | |
| SCHEMBL7009554 | 0.82 | ALDH1A1 (0.36) | TOP1ALDH1A1HTTSTAT3GSK3B | |
| SCHEMBL7013500 | 0.82 | TOP1 (0.40) | TOP1ALDH1A1HTTSTAT3GSK3B | |
| SCHEMBL7011082 | 0.82 | STAT3 (0.43) | TOP1ALDH1A1HTTSTAT3GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0945435-B1 | NOVEL PYRIDONECARBOXYLIC ACID DERIVATIVES OR SALTS THEREOF AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | WAKUNAGA PHARMA CO LTD (JP) | 2003-08-13 | — | — | EP | disclosed |
| US-6136823-A | BACTERICIDES OR VIRICIDES | WAKUNAGA PHARMACEUTICAL CO., LTD. (JP) | 2000-10-24 | — | — | US | disclosed |
| EP-0945435-A1 | NOVEL PYRIDONECARBOXYLIC ACID DERIVATIVES OR SALTS THEREOF AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | WAKUNAGA PHARMACEUTICAL CO., LTD. (JP) | 1999-09-29 | — | — | EP | disclosed |