Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 9/20 | 0.63 |
| ▸ | KDR | P35968 | 7/20 | 0.63 |
| ▸ | TEK | Q02763 | 6/20 | 0.63 |
| ▸ | SRC | P12931 | 6/20 | 0.63 |
| ▸ | RET | P07949 | 12/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | YES1 | P07947 | 1/20 | 0.41 |
| ▸ | LYN | P07948 | 1/20 | 0.41 |
| ▸ | HCK | P08631 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | FGR | P09769 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7005293 | 0.92 | SRC (0.62) | LCKKDRTEKSRCRET | |
| SCHEMBL7005965 | 0.82 | EGFR (0.57) | LCKKDRTEKSRCRET | |
| SCHEMBL7009573 | 0.81 | RET (0.57) | LCKKDRTEKSRCRET | |
| SCHEMBL7009817 | 0.80 | SRC (0.60) | LCKKDRTEKSRCRET | |
| SCHEMBL3787827 | 0.79 | KDR (1.00) | LCKKDRTEKSRCRET | |
| SCHEMBL7008291 | 0.76 | CCR9 (0.51) | LCKKDRTEKSRC | |
| SCHEMBL13020146 | 0.73 | SRC (0.73) | LCKKDRTEKSRCRET | |
| SCHEMBL7006750 | 0.73 | SRC (0.61) | LCKKDRTEKSRCRET | |
| SCHEMBL7007965 | 0.72 | TEK (0.50) | LCKKDRTEKSRCABL1 | |
| SCHEMBL7007563 | 0.72 | KDR (0.62) | LCKKDRTEKSRCRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0970084-B1 | PYRROLO 2,3D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS | BASF AG (DE) | 2003-06-04 | — | — | EP | disclosed |
| EP-0970084-A1 | PYRROLO 2,3D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2000-01-12 | — | — | EP | disclosed |
| WO-1998041525-A1 | PYRROLO[2,3D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 1998-09-24 | — | — | WO | disclosed |