Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 5/20 | 0.62 |
| ▸ | LCK | P06239 | 9/20 | 0.51 |
| ▸ | KDR | P35968 | 6/20 | 0.51 |
| ▸ | TEK | Q02763 | 6/20 | 0.51 |
| ▸ | RET | P07949 | 11/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7010062 | 0.92 | LCK (0.63) | SRCLCKKDRTEKRET | |
| SCHEMBL7009573 | 0.84 | RET (0.57) | SRCLCKKDRTEKRET | |
| SCHEMBL7009817 | 0.80 | SRC (0.60) | SRCLCKKDRTEKRET | |
| SCHEMBL7008291 | 0.77 | CCR9 (0.51) | SRCLCKKDRTEK | |
| SCHEMBL7005965 | 0.74 | EGFR (0.57) | SRCLCKKDRTEKRET | |
| SCHEMBL7006750 | 0.73 | SRC (0.61) | SRCLCKKDRTEKRET | |
| SCHEMBL7007965 | 0.73 | TEK (0.50) | SRCLCKKDRTEK | |
| SCHEMBL19846838 | 0.71 | ALDH1A1 (0.66) | — | |
| SCHEMBL7012535 | 0.71 | SRC (0.78) | SRCLCKKDRTEKRET | |
| SCHEMBL7009724 | 0.71 | LCK (0.74) | SRCLCKKDRTEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0970084-B1 | PYRROLO 2,3D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS | BASF AG (DE) | 2003-06-04 | — | — | EP | disclosed |
| EP-0970084-A1 | PYRROLO 2,3D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2000-01-12 | — | — | EP | disclosed |
| US-6001839-A | Substituted 4-amino-7H-pyrrolo [2,3,-d]-pyrimidines as PTK inhibitors | BASF AKTIENGESELLSCHAFT (DE) | 1999-12-14 | — | — | US | disclosed |
| WO-1998041525-A1 | PYRROLO[2,3D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 1998-09-24 | — | — | WO | disclosed |