Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 7/20 | 0.50 |
| ▸ | LCK | P06239 | 6/20 | 0.50 |
| ▸ | KDR | P35968 | 6/20 | 0.50 |
| ▸ | SRC | P12931 | 5/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | EIF2AK3 | Q9NZJ5 | 9/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | PRKDC | P78527 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7008291 | 0.87 | CCR9 (0.51) | TEKLCKKDRSRCEIF2AK3 | |
| SCHEMBL7009817 | 0.77 | SRC (0.60) | TEKLCKKDRSRCEGFR | |
| SCHEMBL7005545 | 0.74 | SRC (0.69) | TEKLCKKDRSRCEGFR | |
| SCHEMBL7009573 | 0.73 | RET (0.57) | TEKLCKKDRSRCEGFR | |
| SCHEMBL7005208 | 0.73 | TEK (0.55) | TEKLCKKDRSRCEGFR | |
| SCHEMBL7005293 | 0.73 | SRC (0.62) | TEKLCKKDRSRC | |
| SCHEMBL7009724 | 0.73 | LCK (0.74) | TEKLCKKDRSRCEGFR | |
| SCHEMBL7006736 | 0.73 | TEK (0.65) | TEKLCKKDRSRCEGFR | |
| SCHEMBL7010062 | 0.72 | LCK (0.63) | TEKLCKKDRSRCEGFR | |
| SCHEMBL21124196 | 0.72 | EIF2AK3 (0.79) | EIF2AK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0970084-B1 | PYRROLO 2,3D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS | BASF AG (DE) | 2003-06-04 | — | — | EP | disclosed |
| US-6001839-A | Substituted 4-amino-7H-pyrrolo [2,3,-d]-pyrimidines as PTK inhibitors | BASF AKTIENGESELLSCHAFT (DE) | 1999-12-14 | — | — | US | disclosed |