Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | TP53 | P04637 | 5/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7013043 | 0.90 | KCNQ3 (0.48) | MAPTSMN1; SMN2HSD17B10ALOX15ALOX12 | |
| SCHEMBL7012972 | 0.89 | KMT2A (0.43) | MAPTSMN1; SMN2HSD17B10ALOX15ALOX12 | |
| SCHEMBL7008578 | 0.86 | MAPT (0.56) | MAPTSMN1; SMN2HSD17B10ALOX15ALOX12 | |
| SCHEMBL7012423 | 0.83 | MAPT (0.55) | MAPTSMN1; SMN2HSD17B10ALOX15ALOX12 | |
| SCHEMBL7654514 | 0.83 | MAPT (0.56) | MAPTSMN1; SMN2HSD17B10ALOX15ALOX12 | |
| SCHEMBL7009245 | 0.81 | MEN1 (0.42) | MAPTSMN1; SMN2HSD17B10MEN1KMT2A | |
| SCHEMBL7007120 | 0.81 | NAMPT (0.46) | MAPTSMN1; SMN2MEN1KMT2AL3MBTL1 | |
| Hydrochloric Acid SCHEMBL7011120 | 0.81 | NAMPT (0.46) | MAPTSMN1; SMN2MEN1KMT2ATP53 | |
| Hydrochloric Acid SCHEMBL7847160 | 0.81 | MEN1 (0.42) | MAPTSMN1; SMN2HSD17B10MEN1KMT2A | |
| SCHEMBL7010421 | 0.80 | KCNQ3 (0.47) | MAPTSMN1; SMN2HSD17B10ALOX15KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102769-B1 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2003-04-16 | — | — | EP | claimed |
| EP-1102769-B1 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2003-04-16 | — | — | EP | disclosed |
| EP-1102769-A2 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000008020-A2 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-02-17 | — | — | WO | disclosed |