Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.43 |
| ▸ | MEN1 | O00255 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 8/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | HTR1D | P28221 | 2/20 | 0.40 |
| ▸ | HTR1B | P28222 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7011258 | 0.90 | TP53 (0.39) | KMT2AMEN1MAPTLMNASMN1; SMN2 | |
| SCHEMBL7010421 | 0.90 | KCNQ3 (0.47) | KMT2AMAPTLMNASMN1; SMN2RAB9A | |
| SCHEMBL7010110 | 0.89 | MAPT (0.52) | KMT2AMEN1MAPTLMNASMN1; SMN2 | |
| SCHEMBL7013917 | 0.86 | MEN1 (0.45) | KMT2AMEN1MAPTLMNASMN1; SMN2 | |
| SCHEMBL7009245 | 0.82 | MEN1 (0.42) | KMT2AMEN1MAPTLMNASMN1; SMN2 | |
| SCHEMBL7007120 | 0.82 | NAMPT (0.46) | KMT2AMEN1MAPTLMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7011120 | 0.81 | NAMPT (0.46) | KMT2AMEN1MAPTLMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7847160 | 0.81 | MEN1 (0.42) | KMT2AMEN1MAPTLMNASMN1; SMN2 | |
| SCHEMBL7013043 | 0.80 | KCNQ3 (0.48) | KMT2AMEN1MAPTLMNASMN1; SMN2 | |
| SCHEMBL7011226 | 0.80 | MAPT (0.48) | KMT2AMEN1MAPTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102769-B1 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2003-04-16 | — | — | EP | claimed |
| EP-1102769-B1 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2003-04-16 | — | — | EP | disclosed |