Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7847160 | 0.99 | MEN1 (0.42) | MEN1KMT2AUSP2RAB9ANPC1 | |
| SCHEMBL7011258 | 0.91 | TP53 (0.39) | MEN1KMT2AUSP2RAB9ANPC1 | |
| SCHEMBL7007120 | 0.89 | NAMPT (0.46) | MEN1KMT2AUSP2RAB9ANPC1 | |
| Hydrochloric Acid SCHEMBL7011120 | 0.88 | NAMPT (0.46) | MEN1KMT2AUSP2RAB9ANPC1 | |
| SCHEMBL7012350 | 0.87 | ALDH1A1 (0.43) | MEN1KMT2AUSP2RAB9ANPC1 | |
| SCHEMBL7011226 | 0.87 | MAPT (0.48) | MEN1KMT2AMAPTGAAHTT | |
| Hydrochloric Acid SCHEMBL7845602 | 0.86 | ALDH1A1 (0.42) | MEN1KMT2AUSP2RAB9ANPC1 | |
| SCHEMBL7012754 | 0.85 | RORC (0.44) | MEN1KMT2AUSP2RAB9ANPC1 | |
| Hydrochloric Acid SCHEMBL7009820 | 0.84 | RORC (0.44) | MEN1KMT2AUSP2RAB9ANPC1 | |
| SCHEMBL7012972 | 0.82 | KMT2A (0.43) | MEN1KMT2AUSP2RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102769-B1 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2003-04-16 | — | — | EP | claimed |
| EP-1102769-A2 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2001-05-30 | — | — | EP | claimed |
| WO-2000008020-A2 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-02-17 | — | — | WO | claimed |
| EP-1102769-B1 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2003-04-16 | — | — | EP | disclosed |