Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 8/20 | 0.63 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.63 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
| ▸ | KCNA3 | P22001 | 2/20 | 0.60 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11282136 | 0.89 | OPRM1 (0.80) | OPRM1OPRD1OPRK1KDM4ENPSR1 | |
| SCHEMBL6422989 | 0.85 | CHRM2 (0.59) | OPRM1OPRD1OPRK1KDM4E | |
| SCHEMBL23535169 | 0.84 | KDM4E (0.59) | OPRM1OPRD1OPRK1KDM4ENPSR1 | |
| SCHEMBL29664779 | 0.83 | OPRM1 (0.56) | OPRM1OPRD1OPRK1KCNA3SLC22A1 | |
| SCHEMBL2005769 | 0.83 | OPRM1 (0.56) | OPRM1OPRD1OPRK1KCNA3SLC22A1 | |
| SCHEMBL13658282 | 0.83 | OPRM1 (0.56) | OPRM1OPRD1OPRK1KCNA3SLC22A1 | |
| SCHEMBL3411033 | 0.83 | CHRM2 (0.57) | OPRM1OPRD1OPRK1KDM4E | |
| SCHEMBL28944846 | 0.82 | KDM4E (0.47) | OPRM1OPRD1OPRK1KDM4ENPSR1 | |
| SCHEMBL17187971 | 0.82 | OPRM1 (0.72) | OPRM1OPRD1OPRK1KDM4ENPSR1 | |
| SCHEMBL2011106 | 0.81 | OPRM1 (0.53) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124624-B2 | Substituted sulfonamide compounds | GRUENENTHAL GMBH (DE) | 2012-02-28 | — | — | US | disclosed |
| US-8124624-B2 | Substituted sulfonamide compounds | GRUENENTHAL GMBH (DE) | 2012-02-28 | — | — | US | disclosed |
| EP-2262791-A2 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2010-12-22 | — | — | EP | disclosed |
| US-20090264407-A1 | Substituted Sulfonamide Compounds | GRUENENTHAL GMBH (DE) | 2009-10-22 | — | — | US | disclosed |
| US-20090264407-A1 | Substituted Sulfonamide Compounds | GRUENENTHAL GMBH (DE) | 2009-10-22 | — | — | US | disclosed |
| WO-2009124734-A2 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2009-10-15 | — | — | WO | disclosed |
| WO-2009124734-A2 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2009-10-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264407-A1 | Substituted Sulfonamide Compounds | CNR1, SUCNR1, OPRL1 | OPRM1 20/4885OPRD1 28/4885OPRK1 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.