Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F | P30939 | 20/20 | 0.47 |
| ▸ | HTR1D | P28221 | 12/20 | 0.46 |
| ▸ | HTR1B | P28222 | 12/20 | 0.46 |
| ▸ | HTR1A | P08908 | 11/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR1E | P28566 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8460902 | 0.86 | HTR1F (0.46) | HTR1FHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL7008470 | 0.78 | HTR1F (0.56) | HTR1FHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL30908990 | 0.78 | HTR1F (0.56) | HTR1FHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL7011970 | 0.71 | HTR1F (0.82) | HTR1FHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL7009030 | 0.71 | HTR1F (0.79) | HTR1FHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL7013755 | 0.71 | HTR1F (0.67) | HTR1FHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL7007423 | 0.70 | HTR1F (0.57) | HTR1FHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL7008169 | 0.70 | HTR1F (0.74) | HTR1FHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL7012121 | 0.70 | HTR1F (0.75) | HTR1FHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL7013362 | 0.69 | HTR1F (0.64) | HTR1FHTR1DHTR1BHTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0842934-B1 | 5-HT1F agonists | LILLY CO ELI (US) | 2003-10-29 | — | — | EP | disclosed |
| EP-1082958-A2 | 5-HT1F agonists in chronic pain | ELI LILLY AND COMPANY (US) | 2001-03-14 | — | — | EP | disclosed |
| EP-0842934-A1 | 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-05-20 | — | — | EP | disclosed |