Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | DAO | P14920 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | CCKAR | P32238 | 1/20 | 0.52 |
| ▸ | CCKBR | P32239 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL378260 | 0.81 | FLT3 (0.65) | FLT3KDM4EMAPTDAOHPGD | |
| SCHEMBL29595772 | 0.81 | FLT3 (0.65) | FLT3KDM4EMAPTDAOHPGD | |
| Hydrochloric Acid SCHEMBL35211567 | 0.80 | FLT3 (0.62) | FLT3KDM4EMAPTDAOHPGD | |
| SCHEMBL25106917 | 0.78 | FLT3 (0.61) | FLT3KDM4EMAPTDAOHPGD | |
| SCHEMBL34468805 | 0.77 | KDM4E (0.55) | KDM4EHPGDHSD17B10LMNATP53 | |
| SCHEMBL34468811 | 0.76 | KDM4E (0.57) | KDM4EHPGDHSD17B10LMNATP53 | |
| SCHEMBL8152104 | 0.76 | CCKBR (0.52) | FLT3KDM4EMAPTDAOHPGD | |
| SCHEMBL3246966 | 0.76 | PDGFRB (0.57) | FLT3KDM4EMAPTDAOHPGD | |
| SCHEMBL3252732 | 0.76 | FLT3 (0.57) | FLT3KDM4EMAPTDAOHPGD | |
| SCHEMBL30944769 | 0.76 | KDM4E (0.60) | FLT3KDM4EMAPTDAOHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1226138-A4 | FAB I INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2003-03-05 | — | — | EP | disclosed |
| EP-1226138-A1 | FAB I INHIBITORS | SmithKline Beecham Corporation (US) | 2002-07-31 | — | — | EP | disclosed |
| WO-2001027103-A1 | FAB I INHIBITORS | SMITHKLINE BEECHAM CORPORATION (GB) | 2001-04-19 | — | — | WO | disclosed |