SCHEMBL7010678

SCHEMBL7010678

COc1ccccc1C(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
HTR1F P30939 20/20 1.00
HTR1A P08908 18/20 1.00
HTR1B P28222 14/20 1.00
HTR1D P28221 15/20 0.78
HTR2A P28223 2/20 0.68
HTR2C P28335 2/20 0.68
HTR1E P28566 2/20 0.68
HTR4 Q13639 2/20 0.68
HTR6 P50406 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7007507 0.88 HTR1F (1.00) HTR1FHTR1AHTR1BHTR1DHTR2A
SCHEMBL7007151 0.87 HTR1F (0.81) HTR1FHTR1AHTR1BHTR1DHTR2A
SCHEMBL7006550 0.87 HTR1F (1.00) HTR1FHTR1AHTR1BHTR1DHTR2A
SCHEMBL7005306 0.87 HTR1F (0.81) HTR1FHTR1AHTR1BHTR1DHTR2A
SCHEMBL7012876 0.85 HTR1F (0.80) HTR1FHTR1AHTR1BHTR1DHTR2A
SCHEMBL7008481 0.84 HTR1A (1.00) HTR1FHTR1AHTR1BHTR1DHTR2A
SCHEMBL7013510 0.84 HTR1F (1.00) HTR1FHTR1AHTR1BHTR1DHTR2A
SCHEMBL7006511 0.83 HTR1F (0.80) HTR1FHTR1AHTR1BHTR1DHTR2A
SCHEMBL7006603 0.83 HTR1F (0.77) HTR1FHTR1AHTR1BHTR1DHTR2A
SCHEMBL7009522 0.82 HTR1F (1.00) HTR1FHTR1AHTR1BHTR1DHTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1235798-A4 1,4 SUBSTITUTED PIPERIDINYL NMDA/NR2B ANTAGONISTS MERCK & CO INC (US) 2003-04-23 EP claimed
EP-1235798-A1 1,4 SUBSTITUTED PIPERIDINYL NMDA/NR2B ANTAGONISTS Merck & Co., Inc. (US) 2002-09-04 EP claimed
WO-2001032615-A1 1,4 SUBSTITUTED PIPERIDINYL NMDA/NR2B ANTAGONISTS MERCK & CO., INC. (US) 2001-05-10 WO claimed
EP-0842934-B1 5-HT1F agonists LILLY CO ELI (US) 2003-10-29 EP disclosed
EP-1235798-A4 1,4 SUBSTITUTED PIPERIDINYL NMDA/NR2B ANTAGONISTS MERCK & CO INC (US) 2003-04-23 EP disclosed
EP-1235798-A1 1,4 SUBSTITUTED PIPERIDINYL NMDA/NR2B ANTAGONISTS Merck & Co., Inc. (US) 2002-09-04 EP disclosed
WO-2001032615-A1 1,4 SUBSTITUTED PIPERIDINYL NMDA/NR2B ANTAGONISTS MERCK & CO., INC. (US) 2001-05-10 WO disclosed
EP-1082958-A2 5-HT1F agonists in chronic pain ELI LILLY AND COMPANY (US) 2001-03-14 EP disclosed
US-5998622-A ANALGESICS; ANTIINFLAMMATORY AGENTS; SIDE EFFECT REDUCTION ELI LILLY AND COMPANY (US) 1999-12-07 US disclosed
US-5919936-A 5-HT1F AGONIST INTERMEDIATES ELI LILLY AND COMPANY (US) 1999-07-06 US disclosed
US-5817671-A ANTISEROTONIN AGENT; ANALGESICS; MIGRAINE THERAPY; COMPOUND CONTAINING PYRROLO(3,2-B)PYRIDINE RING ELI LILLY AND COMPANY (US) 1998-10-06 US disclosed
EP-0842934-A1 5-HT1F agonists ELI LILLY AND COMPANY (US) 1998-05-20 EP disclosed