Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 9/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 8/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7006695 | 0.79 | ERBB2 (0.47) | CYP1A2CYP3A4CYP2C19CYP2D6CYP11B2 | |
| SCHEMBL14555850 | 0.79 | ERBB2 (0.47) | CYP1A2CYP3A4CYP2C19CYP2D6ALDH1A1 | |
| SCHEMBL7683701 | 0.76 | PRMT5 (0.43) | CYP1A2CYP3A4CYP2C19CYP2D6TSHR | |
| SCHEMBL7014026 | 0.75 | PDK1 (0.43) | CYP1A2CYP3A4ALDH1A1TDP1HPGD | |
| SCHEMBL7685860 | 0.74 | TNF (0.42) | CYP2C19TSHRCYP11B2CYP11B1KDM4E | |
| SCHEMBL7686051 | 0.70 | CYP2A6 (0.42) | CYP1A2CYP3A4CYP2C19CYP2D6TNF | |
| SCHEMBL2559783 | 0.68 | ATM (0.50) | TSHRCYP11B2CYP11B1GRM2ALDH1A1 | |
| SCHEMBL29818856 | 0.68 | L3MBTL1 (0.54) | CYP11B2CYP11B1ALDH1A1MAPK1KDM4E | |
| SCHEMBL26908157 | 0.68 | L3MBTL1 (0.54) | CYP11B2CYP11B1ALDH1A1MAPK1KDM4E | |
| SCHEMBL3837608 | 0.67 | AKT1 (0.58) | CYP1A2CYP3A4CYP2C19CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1327631-A2 | Fused heterocyclic compounds, their production and use as angiotensin II antagonists | Takeda Chemical Industries, Ltd. (JP) | 2003-07-16 | — | — | EP | disclosed |
| EP-0518033-B1 | Fused heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-07-02 | — | — | EP | disclosed |
| US-5389641-A | Fused heterocyclic compounds, having angiotensin II antagonistic activity | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-02-14 | — | — | US | disclosed |
| EP-0518033-A1 | Fused heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-12-16 | — | — | EP | disclosed |