Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL7016458 | 0.90 | ALDH1A1 (0.60) | ALDH1A1LMNAMAPTALOX15 | |
| Bicarbonate SCHEMBL7017171 | 0.90 | PDE10A (0.52) | ALDH1A1LMNAMAPTALOX15PDE5A | |
| SCHEMBL8180123 | 0.90 | ALDH1A1 (0.51) | ALDH1A1LMNAMAPTALOX15PDE10A | |
| Bicarbonate SCHEMBL7018386 | 0.86 | KDM4E (0.46) | ALDH1A1LMNAMAPTALOX15 | |
| Bicarbonate SCHEMBL7018830 | 0.86 | ALDH1A1 (0.41) | ALDH1A1LMNAMAPTALOX15 | |
| Bicarbonate SCHEMBL7016035 | 0.83 | ALDH1A1 (0.42) | ALDH1A1LMNAMAPTPDE5A | |
| Bicarbonate SCHEMBL7015118 | 0.82 | ESR1 (0.42) | ALDH1A1LMNAMAPTALOX15PDE5A | |
| Bicarbonate SCHEMBL7015536 | 0.81 | ALDH1A1 (0.40) | ALDH1A1LMNAMAPTALOX15PDE5A | |
| Bicarbonate SCHEMBL7014095 | 0.81 | HTT (0.51) | ALDH1A1LMNAMAPTPDE5A | |
| Bicarbonate SCHEMBL7018200 | 0.81 | PDE5A (0.47) | ALDH1A1PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934321-B1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 2003-08-06 | — | — | EP | disclosed |
| EP-0934321-A1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GmbH (DE) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998017668-A1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 1998-04-30 | — | — | WO | disclosed |