Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL7010796 | 0.90 | ALDH1A1 (0.49) | ALDH1A1LMNAMAPTALOX15 | |
| Bicarbonate SCHEMBL7018286 | 0.90 | ALDH1A1 (0.57) | ALDH1A1LMNAMAPTALOX15HTT | |
| SCHEMBL8178461 | 0.89 | ALDH1A1 (0.62) | ALDH1A1LMNAMAPTALOX15HTT | |
| Bicarbonate SCHEMBL7013405 | 0.86 | ALDH1A1 (0.49) | ALDH1A1LMNAMAPTALOX15HTT | |
| Bicarbonate SCHEMBL7011659 | 0.86 | ALDH1A1 (0.49) | ALDH1A1LMNAMAPTALOX15HTT | |
| Bicarbonate SCHEMBL7016035 | 0.84 | ALDH1A1 (0.42) | ALDH1A1LMNAMAPTHTTSMN1; SMN2 | |
| Bicarbonate SCHEMBL7014095 | 0.83 | HTT (0.51) | ALDH1A1LMNAMAPTHTTSMN1; SMN2 | |
| Bicarbonate SCHEMBL7018200 | 0.82 | PDE5A (0.47) | ALDH1A1SMN1; SMN2KDM4E | |
| Bicarbonate SCHEMBL7020354 | 0.82 | ALDH1A1 (0.50) | ALDH1A1LMNAMAPTALOX15HTT | |
| Bicarbonate SCHEMBL7017171 | 0.80 | PDE10A (0.52) | ALDH1A1LMNAMAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934321-B1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 2003-08-06 | — | — | EP | disclosed |