Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.34 |
| ▸ | HTR4 | Q13639 | 8/20 | 0.34 |
| ▸ | ACHE | P22303 | 3/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8600560 | 0.69 | MEN1 (0.44) | HTR4ACHEKMT2AMEN1ALDH1A1 | |
| SCHEMBL5458615 | 0.67 | CHRM1 (0.35) | DPP4ACHECHRM4CHRM5CHRM3 | |
| SCHEMBL5345346 | 0.66 | CHRM5 (0.35) | CHRM5CHRM3 | |
| SCHEMBL5345355 | 0.66 | CHRM1 (0.60) | HTR4ACHECHRM4CHRM5ADRA2C | |
| SCHEMBL13597045 | 0.64 | DPP4 (0.53) | DPP4CYP2D6CYP2C9USP2 | |
| SCHEMBL6523687 | 0.64 | ADRA1D (0.41) | HTR4ACHEADRA1B | |
| SCHEMBL4485151 | 0.63 | DPP4 (0.36) | DPP4CHRM4CHRM5CHRM3ADRA1B | |
| SCHEMBL8971080 | 0.62 | ACHE (0.41) | HTR4ACHE | |
| SCHEMBL4510428 | 0.62 | TYR (0.34) | DPP4ACHECHRM4CHRM5CHRM3 | |
| SCHEMBL13596996 | 0.61 | MEN1 (0.57) | ACHEKMT2AMEN1ALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1278741-A1 | MUSCARINIC AGONISTS | Acadia Pharmaceuticals Inc. (US) | 2003-01-29 | — | — | EP | disclosed |
| WO-2001083472-A1 | MUSCARINIC AGONISTS | ACADIA PHARMACEUTICALS, INC. (US) | 2001-11-08 | — | — | WO | disclosed |