Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4324041 | 0.92 | CHRNA7 (0.31) | CHRNA7 | |
| SCHEMBL4324045 | 0.92 | CHRNA7 (0.31) | CHRNA7 | |
| SCHEMBL702087 | 0.91 | OPRK1 (0.33) | CHRNA7 | |
| SCHEMBL702088 | 0.91 | OPRK1 (0.33) | CHRNA7 | |
| SCHEMBL701092 | 0.91 | CHRNA7 (0.31) | CHRNA7 | |
| Lithium Ion SCHEMBL700097 | 0.87 | HTR3A (0.34) | — | |
| SCHEMBL4318408 | 0.81 | HTR3A (0.35) | — | |
| SCHEMBL4318410 | 0.81 | HTR3A (0.35) | — | |
| SCHEMBL701058 | 0.80 | CHRM2 (0.35) | CHRNA7 | |
| SCHEMBL701059 | 0.80 | CHRM2 (0.35) | CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124600-B2 | 5-HT3 receptor modulators, methods of making, and use thereof | ALBANY MOLECULAR RESEARCH, INC. (US) | 2012-02-28 | — | — | US | disclosed |