Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 10/20 | 0.84 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.58 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.58 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.58 |
| ▸ | HTR1A | P08908 | 4/20 | 0.56 |
| ▸ | HTR2A | P28223 | 2/20 | 0.56 |
| ▸ | DRD1 | P21728 | 1/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.56 |
| ▸ | HTR1B | P28222 | 1/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.56 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.55 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6086908 | 0.91 | SLC6A4 (1.00) | SLC6A4OPRM1OPRK1OPRL1HTR1A | |
| SCHEMBL6996942 | 0.85 | SLC6A4 (0.61) | SLC6A4OPRM1OPRK1OPRL1HTR1B | |
| SCHEMBL6642008 | 0.85 | HTR1D (0.63) | SLC6A4OPRM1OPRK1OPRL1HTR1B | |
| SCHEMBL8381443 | 0.85 | CYP1A2 (0.63) | SLC6A4OPRM1OPRK1OPRL1HTR1A | |
| SCHEMBL7002497 | 0.84 | SLC6A4 (0.61) | SLC6A4OPRM1OPRK1OPRL1HTR1A | |
| SCHEMBL6995996 | 0.83 | SLC6A4 (0.59) | SLC6A4OPRM1OPRK1OPRL1HTR1B | |
| SCHEMBL7003242 | 0.82 | SLC6A4 (0.57) | SLC6A4OPRM1OPRK1OPRL1HTR1A | |
| SCHEMBL7014120 | 0.80 | SLC6A4 (0.56) | SLC6A4OPRM1OPRK1OPRL1HTR1A | |
| SCHEMBL6997701 | 0.80 | HTR1D (0.57) | SLC6A4HTR1AHTR1BHSD11B1 | |
| SCHEMBL7014117 | 0.80 | SLC6A4 (0.56) | SLC6A4OPRM1OPRK1OPRL1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1105393-B1 | BICYCLIC PIPERIDINE AND PIPERAZINE COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY | NPS ALLELIX CORP (CA) | 2003-10-01 | — | — | EP | disclosed |
| US-6251893-B1 | TREATING CENTRAL NERVOUS SYSTEM DISORDERS | NPS ALLELIX CORP. (CA) | 2001-06-26 | — | — | US | disclosed |
| US-5874427-A | MIGRAINE | ELI LILLY AND COMPANY (US) | 1999-02-23 | — | — | US | disclosed |
| EP-0875513-A1 | Substituted heteroaromatic 5-HT 1F agonists | ELI LILLY AND COMPANY (US) | 1998-11-04 | — | — | EP | disclosed |
| WO-1998046570-A1 | SUBSTITUTED HETEROAROMATIC 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 1998-10-22 | — | — | WO | disclosed |