Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7008271 | 0.78 | MAPK1 (0.50) | HTR1ADRD2MAPTMAPK1TDP1 | |
| SCHEMBL7009518 | 0.77 | SUV39H2 (0.37) | HTR1ADRD2MAPTMAPK1L3MBTL1 | |
| SCHEMBL7012495 | 0.77 | MAPK1 (0.45) | HTR1ADRD2MAPTMAPK1TDP1 | |
| SCHEMBL6535132 | 0.76 | ABCB1 (0.48) | HTR1ADRD2MAPTMAPK1TDP1 | |
| SCHEMBL7009318 | 0.75 | PTGDR (0.42) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7013077 | 0.75 | MAPT (0.52) | HTR1ASLC6A2SLC6A4SLC6A3DRD2 | |
| SCHEMBL7012498 | 0.72 | HTR1A (0.44) | HTR1ASLC6A2SLC6A4SLC6A3MRGPRX4 | |
| SCHEMBL8327321 | 0.71 | PLA2G1B (0.43) | HTR1ASLC6A2SLC6A4SLC6A3MEN1 | |
| SCHEMBL7010577 | 0.71 | HTR1A (0.46) | HTR1ASLC6A2SLC6A4SLC6A3MAPT | |
| SCHEMBL24738056 | 0.71 | ATP4A (0.37) | HTR1ASLC6A2SLC6A4SLC6A3MRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6645976-B1 | Nonpancreatic secretory phospholipase (sPLA2) supressors such as 2-(3-Benzyl-8-hydroxy-2-ethylindolizin-1-yl)acetamide, administered to control release of fatty acid and prevent the arachidonic acid cascade; septic shock | ELI LILLY AND COMPANY | 2003-11-11 | — | — | US | disclosed |
| EP-0772596-B1 | INDOLIZINE sPLA2 INHIBITORS | LILLY CO ELI (US) | 2003-10-01 | — | — | EP | disclosed |
| CN-1158121-A | Indolizine sPLA2Inhibitors | LILLY CO ELI (US) | 1997-08-27 | — | — | CN | disclosed |