Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 14/20 | 0.53 |
| ▸ | TOP2B | Q02880 | 10/20 | 0.53 |
| ▸ | TOP1 | P11387 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.48 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.47 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8478277 | 1.00 | TOP2A (0.53) | TOP2ATOP2BTOP1POLBCACNA1F | |
| SCHEMBL7010194 | 0.93 | CACNA1F (0.51) | TOP2ATOP2BTOP1POLBCACNA1F | |
| SCHEMBL5868717 | 0.89 | KMT2A (0.60) | TOP2ATOP2BTOP1POLBCACNA1F | |
| SCHEMBL7013670 | 0.86 | TOP2A (0.64) | TOP2ATOP2BTOP1POLBALDH1A1 | |
| SCHEMBL7005373 | 0.85 | CYP3A4 (0.53) | TOP2ATOP2BTOP1POLBCACNA1F | |
| SCHEMBL7014564 | 0.84 | CYP3A4 (0.46) | TOP2ATOP2BTOP1POLBCACNA1F | |
| SCHEMBL7004713 | 0.84 | TOP2A (0.57) | TOP2ATOP2BTOP1POLBALDH1A1 | |
| SCHEMBL8482489 | 0.84 | TOP2A (0.57) | TOP2ATOP2BTOP1POLBALDH1A1 | |
| SCHEMBL7004969 | 0.81 | ALDH1A1 (0.69) | TOP2ATOP2BTOP1POLBALDH1A1 | |
| SCHEMBL8479016 | 0.81 | ALDH1A1 (0.69) | TOP2ATOP2BTOP1POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0787720-B1 | PYRIDONECARBOXYLATE DERIVATIVE OR SALT THEREOF AND ANTIBACTERIAL CONTAINING THE SAME AS ACTIVE INGREDIENT | WAKUNAGA SEIYAKU KK (JP) | 2003-07-16 | — | — | EP | disclosed |
| US-5910498-A | NOVEL COMPOUNDS HAVING REDUCED CYTOTOXICITY, PHOTOTOXICITY; TREATING BACTERIAL AND VIRAL INFECTIONS | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0787720-A1 | NOVEL PYRIDONECARBOXYLATE DERIVATIVE OR SALT THEREOF AND ANTIBACTERIAL CONTAINING THE SAME AS ACTIVE INGREDIENT | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1997-08-06 | — | — | EP | disclosed |