Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 6/20 | 0.47 |
| ▸ | RAMP1 | O60894 | 1/20 | 0.41 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 5/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.39 |
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL7008582 | 0.90 | DPP4 (0.48) | DPP4CALCRLCHRM1DPP7OPRD1 | |
| SCHEMBL7006555 | 0.89 | L3MBTL3 (0.41) | RAMP1CALCRLCHRM1OPRD1SMYD3 | |
| SCHEMBL7014034 | 0.85 | CALCRL (0.43) | RAMP1CALCRLCHRM1OPRD1SMYD3 | |
| SCHEMBL3960017 | 0.82 | DPP8 (0.47) | CALCRLCHRM1SMYD3ALOX15 | |
| Trifluoroacetic Acid SCHEMBL7011220 | 0.82 | DPP4 (0.48) | DPP4CALCRLCHRM1DPP7OPRD1 | |
| SCHEMBL7013786 | 0.81 | CALCRL (0.42) | RAMP1CALCRLCHRM1OPRD1SMYD3 | |
| SCHEMBL7008363 | 0.81 | SMYD3 (0.43) | DPP4OPRD1SMYD3AKT1OPRK1 | |
| SCHEMBL3311183 | 0.80 | OPRK1 (0.39) | RAMP1CALCRLCHRM1OPRD1SMYD3 | |
| SCHEMBL29496465 | 0.80 | CHRM1 (0.58) | DPP4CHRM1OPRD1ALOX15OPRK1 | |
| SCHEMBL5248991 | 0.80 | RAMP1 (0.59) | DPP4RAMP1CALCRLCHRM1DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1163239-B1 | MODIFIED AMINO-ACID AMIDES AS CGRP ANTAGONISTS | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-05-28 | — | — | EP | disclosed |
| US-6313097-B1 | TREATMENT OR PROPHYLAXIS OF MIGRAINE OR CLUSTER HEADACHES, NON-INSULIN-DEPENDENT DIABETES MELLITUS, INFLAMMATION, ALLERGIC RHINITIS, ASTHMA, MORPHINE TOLERANCE, MENOPAUSAL HOT FLASHES, DISEASES CHARACTERIZED BY EXCESSIVE VASODILATATION | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-11-06 | — | — | US | disclosed |