SCHEMBL701268

SCHEMBL701268

Cc1c(Br)ccc(S(C)(=O)=O)c1C1=NOCC1

nearest known ligand 0.47

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
EDNRB P24530 1/20 0.30
EDNRA P25101 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL28689439 0.99
SCHEMBL28008116 0.89 EDNRB (0.30) EDNRBEDNRA
SCHEMBL700999 0.88
SCHEMBL699409 0.86 EDNRB (0.32) EDNRBEDNRA
SCHEMBL14844544 0.85
SCHEMBL30758079 0.83
SCHEMBL702571 0.83 LMNA (0.31) EDNRBEDNRA
SCHEMBL29171450 0.83
SCHEMBL700751 0.83 EDNRB (0.30) EDNRBEDNRA
SCHEMBL700478 0.83

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 117 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120025324-A Topramezone and its preparation method Process for synthesizing ketone 安徽丰乐农化有限责任公司 2025-05-23 CN claimed
CN-118788251-B Method for preparing 3- [ 3-bromo-2-methyl-6- (methylsulfonyl) phenyl ] -4, 5-dihydroisoxazole 苏州开元民生科技股份有限公司 2025-02-07 CN claimed
CN-119371413-A Topramezone and its preparation method Process for the preparation of ketones 安徽丰乐农化有限责任公司 2025-01-28 CN claimed
CN-119350263-A Preparation method of 3- (3-bromo-2-methyl-6-methylsulfonylphenyl) -4, 5-dihydroisoxazole 江西天宇化工有限公司 2025-01-24 CN claimed
CN-118788251-A Method for preparing 3- [ 3-bromo-2-methyl-6- (methylsulfonyl) phenyl ] -4, 5-dihydroisoxazole 苏州开元民生科技股份有限公司 2024-10-18 CN claimed
CN-117551090-A Method for synthesizing topramezone by photocatalysis 江苏农牧科技职业学院 2024-02-13 CN claimed
CN-115322185-B Preparation method of topramezone 潍坊新绿化工有限公司 2023-01-31 CN claimed
CN-115322185-A Preparation method of topramezone 潍坊新绿化工有限公司 2022-11-11 CN claimed
CN-111848536-B Preparation method of 3- [ 3-bromo-2-methyl-6- (methylsulfonyl) phenyl ] -4, 5-dihydroisoxazole 山东京博生物科技有限公司 2022-04-12 CN claimed
CN-111848536-A Preparation method of 3- [ 3-bromo-2-methyl-6- (methylsulfonyl) phenyl ] -4, 5-dihydroisoxazole 山东京博生物科技有限公司 2020-10-30 CN claimed
CN-107652246-B Preparation method of 3- [ 3-bromo-2-methyl-6- (methylsulfonyl) phenyl ] -4, 5-dihydro isoxazole 江苏乾元生物科技有限公司 2020-08-25 CN claimed
CN-111440160-A Preparation method and application of topramezone 黑龙江省绥化农垦晨环生物制剂有限责任公司 2020-07-24 CN claimed
EP-1131307-B1 METHOD OF PRODUCING 2-ALKYL-3-(4,5-DIHYDROISOXAZOLE-3-YL)-HALOBENZENES BASF AG (DE) 2004-08-25 EP claimed
US-20030229232-A1 Herbicides RACK MICHAEL (DE) 2003-12-11 US claimed
US-6548677-B1 Halogenating o-xylene; reacting with hydrogen peroxide and halogenating agent to form a benzyl halide; oxidation to aldehyde; oximination, cyclization, and sulfiding BASF AKTIENGESELLSCHAFT (DE) 2003-04-15 US claimed
CN-120842163-B Synthesis method of topramezone intermediate 3- [ 3-bromo-2-methyl-6- (methylsulfonyl) phenyl ] -4, 5-dihydroisoxazole 苏州开元民生科技股份有限公司 2025-11-21 CN disclosed
CN-120842163-A Synthesis method of topramezone intermediate 3- [ 3-bromo-2-methyl-6- (methylsulfonyl) phenyl ] -4, 5-dihydroisoxazole 苏州开元民生科技股份有限公司 2025-10-28 CN disclosed
EP-1129082-A1 METHOD AND NOVEL INTERMEDIATE PRODUCTS FOR PRODUCING ISOXAZOLIN-3-YL-ACYLBENZENES BASF AKTIENGESELLSCHAFT (DE) 2001-09-05 EP disclosed
CN-1300284-A Preparation of isoxazolin-3-yl-acylbenzenes BASF AG (DE) 2001-06-20 CN disclosed
WO-2000029394-A1 METHOD AND NOVEL INTERMEDIATE PRODUCTS FOR PRODUCING ISOXAZOLIN-3-YL-ACYLBENZENES BASF AKTIENGESELLSCHAFT (DE) 2000-05-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030229232-A1 Herbicides CBR3, CBR1, SULT1E1 EDNRB 3761/4885EDNRA 4531/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.