Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 10/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6433684 | 0.90 | SMN1; SMN2 (0.70) | SMN1; SMN2CYP2C9CYP3A4CYP2D6CYP1A2 | |
| SCHEMBL6360390 | 0.90 | CYP3A4 (0.59) | SMN1; SMN2CYP2C9CYP3A4CYP2D6CYP1A2 | |
| SCHEMBL7009452 | 0.84 | CYP3A4 (0.70) | SMN1; SMN2CYP2C9CYP3A4CYP2D6CYP1A2 | |
| SCHEMBL6356136 | 0.81 | SMN1; SMN2 (0.60) | SMN1; SMN2CYP2C9CYP3A4CYP2D6CYP1A2 | |
| SCHEMBL7496961 | 0.80 | SMN1; SMN2 (0.61) | SMN1; SMN2CYP2C9CYP3A4CYP2D6CYP1A2 | |
| SCHEMBL6356150 | 0.79 | CYP3A4 (0.68) | SMN1; SMN2CYP2C9CYP3A4CYP2D6CYP1A2 | |
| SCHEMBL7495170 | 0.79 | SMN1; SMN2 (0.66) | SMN1; SMN2CYP2C9CYP3A4CYP2D6CYP1A2 | |
| SCHEMBL7013061 | 0.79 | CYP3A4 (0.51) | CYP2C9CYP3A4CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL6353230 | 0.78 | CYP3A4 (0.61) | SMN1; SMN2CYP2C9CYP3A4CYP2D6CYP1A2 | |
| SCHEMBL5633681 | 0.78 | SMN1; SMN2 (0.60) | SMN1; SMN2CYP2C9CYP3A4CYP2D6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6613775-B1 | 8-(2,6-dimethylbenzylamino)-2-hydroxymethyl-3-methylimidazo(1, 2-a)pyridine used as antisecretory agents for prophylaxis of gastrointestinal disorders such as ulcers | ASTRAZENECA AB (SE) | 2003-09-02 | — | — | US | disclosed |
| EP-1105390-B1 | Imidazo[1,2-a]pyridine derivatives for the treatment of gastrointestinal diseases | ASTRAZENECA AB (SE) | 2003-06-04 | — | — | EP | disclosed |
| EP-1105390-A2 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2001-06-13 | — | — | EP | disclosed |
| WO-2000010999-A2 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 2000-03-02 | — | — | WO | disclosed |