Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6433684 | 0.88 | SMN1; SMN2 (0.70) | SMN1; SMN2CYP1A2CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL6356136 | 0.85 | SMN1; SMN2 (0.60) | SMN1; SMN2CYP1A2CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL7496961 | 0.80 | SMN1; SMN2 (0.61) | SMN1; SMN2CYP1A2CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL7012733 | 0.79 | SMN1; SMN2 (0.56) | SMN1; SMN2CYP1A2CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL6354022 | 0.76 | CYP3A4 (0.52) | SMN1; SMN2CYP1A2CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL7494111 | 0.76 | CYP3A4 (0.62) | SMN1; SMN2CYP1A2CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL6350950 | 0.75 | SMN1; SMN2 (0.54) | SMN1; SMN2CYP1A2CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL6356150 | 0.75 | CYP3A4 (0.68) | SMN1; SMN2CYP1A2CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL7502575 | 0.75 | SMN1; SMN2 (0.78) | SMN1; SMN2CYP1A2CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL20579804 | 0.75 | SMN1; SMN2 (0.78) | SMN1; SMN2CYP1A2CYP2C9CYP2C19CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0971920-B1 | COMPOUNDS FOR INHIBITION OF GASTRIC ACID SECRETION | ASTRAZENECA AB (SE) | 2002-06-05 | — | — | EP | disclosed |
| US-6265415-B1 | ANTIULCER AGENT | ASTRAZENECA AB (SE) | 2001-07-24 | — | — | US | disclosed |
| EP-0971920-A1 | COMPOUNDS FOR INHIBITION OF GASTRIC ACID SECRETION | Astra Aktiebolag (SE) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998037080-A1 | COMPOUNDS FOR INHIBITION OF GASTRIC ACID SECRETION | ASTRA AKTIEBOLAG (SE) | 1998-08-27 | — | — | WO | disclosed |