SCHEMBL7012840

SCHEMBL7012840

CCOC(=O)c1cn(-c2cc([N+](=O)[O-])c(F)cc2F)c2cc(F)c(F)cc2c1=O

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.55
LMNA P02545 4/20 0.55
MAPT P10636 4/20 0.55
NPC1 O15118 1/20 0.55
KMT2A Q03164 2/20 0.53
POLB P06746 3/20 0.52
HPGD P15428 3/20 0.49
KDM4E B2RXH2 2/20 0.49
HSD17B10 Q99714 2/20 0.49
STAT3 P40763 2/20 0.46
ROCK2 O75116 1/20 0.43
CDK1 P06493 1/20 0.43
PRKACA P17612 1/20 0.43
CDK2 P24941 1/20 0.43
CSNK1D P48730 1/20 0.43
GSK3A P49840 1/20 0.43
CDK5 Q00535 1/20 0.43
PRKCD Q05655 1/20 0.43
ROCK1 Q13464 1/20 0.43
CDC42BPA Q5VT25 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7007646 0.91 ALDH1A1 (0.60) ALDH1A1LMNAMAPTNPC1KMT2A
SCHEMBL7011336 0.89 ALDH1A1 (0.55) ALDH1A1LMNAMAPTNPC1KMT2A
SCHEMBL19729388 0.88 ALDH1A1 (0.50) ALDH1A1LMNAMAPTNPC1KMT2A
SCHEMBL7008215 0.87 STAT3 (0.60) ALDH1A1LMNAMAPTNPC1KMT2A
SCHEMBL7012447 0.84 TOP1 (0.48) ALDH1A1LMNAMAPTKMT2APOLB
SCHEMBL7008195 0.84 STAT3 (0.52) ALDH1A1LMNAMAPTNPC1KMT2A
SCHEMBL7007378 0.84 ALDH1A1 (0.51) ALDH1A1LMNAMAPTNPC1KMT2A
SCHEMBL7005217 0.83 KMT2A (0.56) ALDH1A1LMNAMAPTNPC1KMT2A
SCHEMBL7006600 0.82 KMT2A (0.54) ALDH1A1LMNAMAPTNPC1KMT2A
SCHEMBL7007413 0.81 STAT3 (0.65) ALDH1A1LMNAMAPTNPC1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1357904-A2 USE OF PYRAZOLO 4,3-D]PYRIMIDINES MERCK PATENT GmbH (DE) 2003-11-05 EP disclosed
EP-1355649-A2 PHARMACEUTICAL FORMULATION CONTAINING PYRAZOLO 4,3-D]PYRIMIDINE AND NITRATES OR THIENOPYRIMIDINES AND NITRATES MERCK PATENT GmbH (DE) 2003-10-29 EP disclosed
EP-1343506-A1 PHARMACEUTICAL FORMULATION CONTAINING PYRAZOLO 4,3-D]PYRIMIDINES AND ANTITHROMBOTIC AGENTS, CALCIUM-ANTAGONISTS, PROSTAGLANDINS OR PROSTAGLANDIN DERIVATIVES MERCK PATENT GmbH (DE) 2003-09-17 EP disclosed
EP-1339410-A1 USE OF PYRAZOLO 4,3-D]PYRIMIDINES MERCK PATENT GmbH (DE) 2003-09-03 EP disclosed
EP-0787720-B1 PYRIDONECARBOXYLATE DERIVATIVE OR SALT THEREOF AND ANTIBACTERIAL CONTAINING THE SAME AS ACTIVE INGREDIENT WAKUNAGA SEIYAKU KK (JP) 2003-07-16 EP disclosed
WO-2002060449-A2 PHARMACEUTICAL FORMULATION CONTAINING PYRAZOLO[4,3-D]PYRIMIDINE AND NITRATES OR THIENOPYRIMIDINES AND NITRATES MERCK PATENT GMBH (DE) 2002-08-08 WO disclosed
WO-2002049651-A1 PHARMACEUTICAL FORMULATION CONTAINING PYRAZOLO[4,3-D]PYRIMIDINES AND ANTITHROMBOTIC AGENTS, CALCIUM-ANTAGONISTS, PROSTAGLANDINS OR PROSTAGLANDIN DERIVATIVES MERCK PATENT GMBH (DE) 2002-06-27 WO disclosed
WO-2002045716-A1 USE OF PYRAZOLO[4,3-D]PYRIMIDINES MERCK PATENT GMBH (DE) 2002-06-13 WO disclosed
EP-1210349-A2 PYRAZOLO 4,3-d]PYRIMIDINES MERCK PATENT GmbH (DE) 2002-06-05 EP disclosed
WO-2002041880-A2 USE OF PYRAZOLO[4,3-D]PYRIMIDINES MERCK PATENT GMBH (DE) 2002-05-30 WO disclosed
WO-2001018004-A2 PYRAZOLO[4,3-d]PYRIMIDINES MERCK PATENT GMBH (DE) 2001-03-15 WO disclosed
US-5910498-A NOVEL COMPOUNDS HAVING REDUCED CYTOTOXICITY, PHOTOTOXICITY; TREATING BACTERIAL AND VIRAL INFECTIONS WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) 1999-06-08 US disclosed
EP-0787720-A1 NOVEL PYRIDONECARBOXYLATE DERIVATIVE OR SALT THEREOF AND ANTIBACTERIAL CONTAINING THE SAME AS ACTIVE INGREDIENT WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) 1997-08-06 EP disclosed