Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7015900 | 0.89 | CRHR1 (0.47) | CRHR1 | |
| SCHEMBL7016641 | 0.80 | CRHR1 (0.47) | CRHR1 | |
| SCHEMBL7020442 | 0.79 | CRHR1 (0.49) | CRHR1 | |
| SCHEMBL7013499 | 0.76 | CRHR1 (0.44) | CRHR1 | |
| SCHEMBL7010343 | 0.74 | CRHR1 (0.49) | CRHR1 | |
| SCHEMBL7014572 | 0.74 | CRHR1 (0.46) | CRHR1 | |
| SCHEMBL7018123 | 0.73 | CRHR1 (0.48) | CRHR1 | |
| SCHEMBL6393855 | 0.72 | CRHR1 (0.63) | CRHR1 | |
| SCHEMBL5866738 | 0.72 | CRHR1 (0.49) | CRHR1 | |
| Hydrazine SCHEMBL6797950 | 0.71 | CRHR1 (0.61) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0920429-B1 | SUBSTITUTED PYRIDO- OR PYRIMIDO-CONTAINING 6,6- OR 6,7-BICYCLIC DERIVATIVES | PFIZER (US) | 2003-02-19 | — | — | EP | disclosed |
| US-6492520-B1 | COMPOUNDS (I) ARE CORTICOTROPIN RELEASING FACTOR (HORMONE) CRF (CRH) ANTAGONISTS. | PFIZER INC | 2002-12-10 | — | — | US | disclosed |
| EP-0920429-A1 | SUBSTITUTED PYRIDO- OR PYRIMIDO-CONTAINING 6,6- OR 6,7-BICYCLIC DERIVATIVES | PFIZER INC. (US) | 1999-06-09 | — | — | EP | disclosed |
| WO-1998005661-A1 | SUBSTITUTED PYRIDO- OR PYRIMIDO-CONTAINING 6,6- OR 6,7-BICYCLIC DERIVATIVES | PFIZER INC. (US) | 1998-02-12 | — | — | WO | disclosed |