Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7684228 | 0.89 | CRHR1 (0.43) | CRHR1LMNAGAA | |
| SCHEMBL8469464 | 0.81 | CRHR1 (0.31) | CRHR1 | |
| SCHEMBL7016669 | 0.79 | CRHR1 (0.41) | CRHR1 | |
| SCHEMBL5866766 | 0.76 | CRHR1 (0.38) | CRHR1 | |
| SCHEMBL7013018 | 0.76 | CRHR1 (0.48) | CRHR1 | |
| SCHEMBL5867014 | 0.76 | CRHR1 (0.35) | CRHR1 | |
| SCHEMBL7683348 | 0.73 | CRHR1 (0.41) | CRHR1 | |
| SCHEMBL5866772 | 0.71 | CRHR1 (0.35) | CRHR1 | |
| SCHEMBL5866999 | 0.71 | CRHR1 (0.60) | CRHR1 | |
| SCHEMBL5867006 | 0.71 | CRHR1 (0.38) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0920429-B1 | SUBSTITUTED PYRIDO- OR PYRIMIDO-CONTAINING 6,6- OR 6,7-BICYCLIC DERIVATIVES | PFIZER (US) | 2003-02-19 | — | — | EP | disclosed |
| US-6492520-B1 | COMPOUNDS (I) ARE CORTICOTROPIN RELEASING FACTOR (HORMONE) CRF (CRH) ANTAGONISTS. | PFIZER INC | 2002-12-10 | — | — | US | disclosed |