Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 3/20 | 0.41 |
| ▸ | EDNRA | P25101 | 3/20 | 0.41 |
| ▸ | SRC | P12931 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 4/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4427054 | 0.91 | EDNRB (0.43) | EDNRBEDNRASRCMEN1KMT2A | |
| SCHEMBL7009624 | 0.87 | EDNRB (0.41) | EDNRBEDNRASRCMEN1KMT2A | |
| SCHEMBL7013169 | 0.81 | IDH1 (0.42) | EDNRBEDNRAMEN1KMT2AHTT | |
| SCHEMBL4435549 | 0.81 | EDNRB (0.44) | EDNRBEDNRASRCMEN1KMT2A | |
| Alcohol SCHEMBL8637347 | 0.81 | EDNRB (0.40) | EDNRBEDNRASRCHTR2ASLC6A4 | |
| SCHEMBL4434185 | 0.75 | DHPS (0.42) | EDNRBEDNRASRCSCN9AHTR2A | |
| SCHEMBL8328712 | 0.74 | KMT2A (0.37) | EDNRBEDNRAMEN1KMT2AHTT | |
| SCHEMBL7298739 | 0.74 | CDK1 (0.43) | EDNRBEDNRAMEN1KMT2AHTR2A | |
| SCHEMBL7586198 | 0.73 | KDM4E (0.47) | EDNRBEDNRAMEN1KMT2ALMNA | |
| SCHEMBL8634388 | 0.72 | HTR2A (0.36) | EDNRBEDNRASRCSCN9AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0601386-B1 | Sulphonamides | HOFFMANN LA ROCHE (CH) | 2003-02-05 | — | — | EP | disclosed |
| US-5420129-A | Treatment of hypertension, ischemia, vasospasms, angina | HOFFMANN-LA ROCHE INC. (US) | 1995-05-30 | — | — | US | disclosed |
| EP-0601386-A1 | Sulphonamides | F. HOFFMANN-LA ROCHE AG (CH) | 1994-06-15 | — | — | EP | disclosed |