Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7010336 | 0.88 | DHPS (0.41) | IDH1RAB9ALMNAALDH1A1TSHR | |
| SCHEMBL7013160 | 0.81 | EDNRB (0.41) | LMNAALDH1A1SMN1; SMN2TSHRMEN1 | |
| SCHEMBL4427054 | 0.76 | EDNRB (0.43) | LMNAALDH1A1SMN1; SMN2TSHRMEN1 | |
| SCHEMBL7011888 | 0.73 | EDNRA (0.57) | EDNRBEDNRA | |
| SCHEMBL8328712 | 0.73 | KMT2A (0.37) | RAB9ALMNAALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL7009624 | 0.72 | EDNRB (0.41) | RAB9ALMNAALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL7586198 | 0.71 | KDM4E (0.47) | LMNAMEN1KMT2AEDNRBEDNRA | |
| SCHEMBL1257596 | 0.70 | DHPS (0.52) | EDNRBEDNRA | |
| SCHEMBL1937757 | 0.70 | EDNRA (0.49) | CYP19A1EDNRBEDNRA | |
| SCHEMBL7298739 | 0.70 | CDK1 (0.43) | RAB9ALMNAALDH1A1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0601386-B1 | Sulphonamides | HOFFMANN LA ROCHE (CH) | 2003-02-05 | — | — | EP | disclosed |
| US-5420129-A | Treatment of hypertension, ischemia, vasospasms, angina | HOFFMANN-LA ROCHE INC. (US) | 1995-05-30 | — | — | US | disclosed |
| EP-0601386-A1 | Sulphonamides | F. HOFFMANN-LA ROCHE AG (CH) | 1994-06-15 | — | — | EP | disclosed |