Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 4/20 | 0.57 |
| ▸ | BRD2 | P25440 | 1/20 | 0.57 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.57 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8648439 | 0.82 | BRD4 (0.44) | BRD4BRD2BRD3BRDTMAPK1 | |
| SCHEMBL7011108 | 0.82 | LMNA (0.84) | MAPK1LMNAPOLBALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7019827 | 0.81 | LMNA (0.82) | MAPK1LMNAPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL2795748 | 0.81 | POLB (0.75) | BRD4BRD2BRD3BRDTMAPK1 | |
| SCHEMBL18989773 | 0.81 | SMN1; SMN2 (0.67) | BRD4BRD2BRD3BRDTMAPK1 | |
| SCHEMBL7018390 | 0.80 | LMNA (0.69) | MAPK1LMNAPOLBSMN1; SMN2GAA | |
| SCHEMBL27794931 | 0.80 | POLB (0.73) | BRD4BRD2BRD3BRDTMAPK1 | |
| SCHEMBL12687220 | 0.79 | KDM4E (0.56) | BRD4BRD2BRD3BRDTMAPK1 | |
| SCHEMBL7015123 | 0.78 | LMNA (0.66) | MAPK1LMNAPOLBMEN1KMT2A | |
| SCHEMBL7015993 | 0.78 | LMNA (0.66) | BRD4BRD2BRD3BRDTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733633-B1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-05-28 | — | — | EP | disclosed |
| US-5753664-A | ANTITUMOR AGENTS, PYRIMIDONES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-05-19 | — | — | US | disclosed |
| EP-0733633-A1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-09-25 | — | — | EP | disclosed |