Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.41 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.41 |
| ▸ | PLA2G6 | O60733 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29682135 | 0.76 | L3MBTL1 (0.80) | L3MBTL1POLBSMN1; SMN2GLAALDH1A1 | |
| SCHEMBL340762 | 0.76 | L3MBTL1 (0.80) | L3MBTL1POLBSMN1; SMN2GLAALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL28240461 | 0.74 | L3MBTL1 (0.77) | L3MBTL1POLBSMN1; SMN2GLAALDH1A1 | |
| SCHEMBL17972755 | 0.74 | L3MBTL1 (0.50) | L3MBTL1POLBSMN1; SMN2GLAALDH1A1 | |
| SCHEMBL8322723 | 0.72 | PLA2G1B (0.49) | POLBSMN1; SMN2PLA2G2APLA2G10PLA2G1B | |
| SCHEMBL10202539 | 0.72 | MEN1 (0.55) | L3MBTL1POLBSMN1; SMN2GLAALDH1A1 | |
| SCHEMBL1145948 | 0.71 | KMT2A (0.62) | L3MBTL1POLBSMN1; SMN2GLAALDH1A1 | |
| SCHEMBL8115884 | 0.71 | L3MBTL1 (0.71) | L3MBTL1POLBSMN1; SMN2GLAALDH1A1 | |
| Succinic Acid SCHEMBL6888240 | 0.71 | L3MBTL1 (0.71) | L3MBTL1POLBSMN1; SMN2GLAALDH1A1 | |
| SCHEMBL17311050 | 0.70 | L3MBTL1 (0.54) | L3MBTL1POLBSMN1; SMN2GLAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6645976-B1 | Nonpancreatic secretory phospholipase (sPLA2) supressors such as 2-(3-Benzyl-8-hydroxy-2-ethylindolizin-1-yl)acetamide, administered to control release of fatty acid and prevent the arachidonic acid cascade; septic shock | ELI LILLY AND COMPANY | 2003-11-11 | — | — | US | disclosed |
| EP-0772596-B1 | INDOLIZINE sPLA2 INHIBITORS | LILLY CO ELI (US) | 2003-10-01 | — | — | EP | disclosed |
| EP-0772596-A4 | INDOLIZINE sPLA2 INHIBITORS | LILLY CO ELI (US) | 1999-01-13 | — | — | EP | disclosed |
| EP-0772596-A1 | INDOLIZINE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003383-A1 | INDOLIZINE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1996-02-08 | — | — | WO | disclosed |