Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.65 |
| ▸ | TEK | Q02763 | 7/20 | 0.65 |
| ▸ | CDK8 | P49336 | 4/20 | 0.56 |
| ▸ | BRAF | P15056 | 3/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.53 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | CDK7 | P50613 | 1/20 | 0.49 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.49 |
| ▸ | MTOR | P42345 | 1/20 | 0.49 |
| ▸ | RAF1 | P04049 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7017943 | 0.95 | KDR (0.71) | KDRTEKCDK8BRAFMAPK14 | |
| SCHEMBL5349168 | 0.91 | TEK (0.79) | KDRTEKCDK8RAF1 | |
| SCHEMBL7013365 | 0.90 | KDR (0.58) | KDRTEKCDK8BRAFMAPK14 | |
| SCHEMBL7020344 | 0.88 | TEK (0.72) | KDRTEKCDK8BRAFMAPK14 | |
| SCHEMBL7015248 | 0.87 | KDR (0.54) | KDRTEKBRAFMTORRAF1 | |
| SCHEMBL7095826 | 0.86 | KDR (0.66) | KDRTEKBRAFMTOR | |
| SCHEMBL5357494 | 0.86 | KDR (0.86) | KDRTEKBRAFMAPK14TNNI3K | |
| SCHEMBL7014470 | 0.85 | KDR (0.63) | KDRTEKMTOR | |
| SCHEMBL5342331 | 0.85 | KDR (0.63) | KDRTEKCDK8NTRK1KMT2A | |
| SCHEMBL7017627 | 0.84 | KDR (0.51) | KDRTEKCDK8BRAFMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341771-A2 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TIE-2 AND/OR VEGFR-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-09-10 | — | — | EP | claimed |
| WO-2002044156-A2 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TIE-2 AND/OR VEGFR-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2002-06-06 | — | — | WO | claimed |