Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 7/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.51 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7015107 | 0.83 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DSLC22A12 | |
| SCHEMBL7013430 | 0.80 | PDE4A (0.63) | PDE4APDE4BPDE4CPDE4DSLC22A12 | |
| SCHEMBL7015062 | 0.70 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DSLC22A12 | |
| SCHEMBL7019078 | 0.68 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL20525065 | 0.66 | L3MBTL1 (0.36) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL21436536 | 0.65 | PLAU (0.40) | — | |
| SCHEMBL16044313 | 0.63 | GAA (0.35) | — | |
| SCHEMBL20516612 | 0.63 | CRHR1 (0.36) | — | |
| SCHEMBL16650333 | 0.63 | KDM4E (0.37) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6604819 | 0.62 | F2RL3 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1086106-B1 | FUROPYRIDINE DERIVATIVES AND THEIR THERAPEUTICAL USE | DARWIN DISCOVERY LTD (GB) | 2003-08-20 | — | — | EP | disclosed |
| EP-1086106-A1 | FUROPYRIDINE DERIVATIVES AND THEIR THERAPEUTICAL USE | Darwin Discovery Limited (GB) | 2001-03-28 | — | — | EP | disclosed |
| US-6169090-B1 | FOR INHIBITION OF PHOSPHODIESTERASE IV | DARWIN DISCOVERY, LTD. (GB) | 2001-01-02 | — | — | US | disclosed |
| WO-1999064423-A1 | FUROPYRIDINE DERIVATIVES AND THEIR THERAPEUTICAL USE | DARWIN DISCOVERY LIMITED (GB) | 1999-12-16 | — | — | WO | disclosed |