Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 5/20 | 0.57 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7741998 | 0.93 | PLA2G7 (0.60) | PLA2G7HPGDALDH1A1GFERSMN1; SMN2 | |
| SCHEMBL8139957 | 0.93 | PLA2G7 (0.60) | PLA2G7HPGDALDH1A1GFERSMN1; SMN2 | |
| SCHEMBL8135226 | 0.88 | PLA2G7 (0.63) | PLA2G7HPGDALDH1A1GFERSMN1; SMN2 | |
| SCHEMBL8133945 | 0.86 | PLA2G7 (0.65) | PLA2G7HPGDALDH1A1GFERSMN1; SMN2 | |
| SCHEMBL8139622 | 0.84 | PLA2G7 (0.58) | PLA2G7HPGDALDH1A1GFERSMN1; SMN2 | |
| SCHEMBL8141713 | 0.84 | PLA2G7 (0.58) | PLA2G7HPGDALDH1A1GFERSMN1; SMN2 | |
| SCHEMBL8132048 | 0.83 | PLA2G7 (0.60) | PLA2G7HPGDALDH1A1MAPTGFER | |
| SCHEMBL8134087 | 0.83 | PLA2G7 (0.51) | PLA2G7KMT2AMAOB | |
| SCHEMBL8138827 | 0.82 | PLA2G7 (0.58) | PLA2G7HPGDALDH1A1GFERSMN1; SMN2 | |
| SCHEMBL8141412 | 0.82 | PLA2G7 (0.48) | PLA2G7SMN1; SMN2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028955-B1 | PYRIMIDINONE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITHKLINE BEECHAM PLC (GB) | 2003-07-16 | — | — | EP | claimed |