Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 11/20 | 0.60 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | DAO | P14920 | 1/20 | 0.45 |
| ▸ | XDH | P47989 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8139957 | 1.00 | PLA2G7 (0.60) | PLA2G7MAOBSMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL8135226 | 0.93 | PLA2G7 (0.63) | PLA2G7MAOBSMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL7013476 | 0.93 | PLA2G7 (0.57) | PLA2G7MAOBSMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL8134087 | 0.90 | PLA2G7 (0.51) | PLA2G7MAOB | |
| SCHEMBL8139622 | 0.89 | PLA2G7 (0.58) | PLA2G7MAOBSMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL8133945 | 0.89 | PLA2G7 (0.65) | PLA2G7MAOBSMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL8139443 | 0.88 | PLA2G7 (0.48) | PLA2G7MAOBSMN1; SMN2HPGDGFER | |
| SCHEMBL8141412 | 0.88 | PLA2G7 (0.48) | PLA2G7MAOBSMN1; SMN2 | |
| SCHEMBL8132048 | 0.88 | PLA2G7 (0.60) | PLA2G7MAOBSMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL8141713 | 0.87 | PLA2G7 (0.58) | PLA2G7MAOBSMN1; SMN2NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028955-A1 | PYRIMIDINONE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SmithKline Beecham p.l.c. (GB) | 2000-08-23 | — | — | EP | claimed |
| WO-1999024420-A1 | PYRIMIDINONE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITHKLINE BEECHAM PLC (GB) | 1999-05-20 | — | — | WO | claimed |
| US-6417192-B1 | DRUGS WITH PYRIMIDONE COMPOUNDS INHIBITORS OF THE ENZYME LDL PLA.SUB.2 AND THEREFORE OF USE IN TREATING ATHEROSCLEROSIS. | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-07-09 | — | — | US | disclosed |