Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.49 |
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.49 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.49 |
| ▸ | DRD4 | P21917 | 2/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 3/20 | 0.39 |
| ▸ | HTR4 | Q13639 | 3/20 | 0.39 |
| ▸ | CYP2J2 | P51589 | 3/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5332206 | 0.90 | CHRM1 (0.59) | DRD2CHRM1HTR1ACHRM2CHRM4 | |
| SCHEMBL5336314 | 0.83 | DRD2 (0.53) | DRD2CHRM1HTR1ACHRM2CHRM4 | |
| SCHEMBL5335803 | 0.79 | DRD2 (0.61) | DRD2CHRM1HTR1ACHRM2CHRM4 | |
| SCHEMBL4510566 | 0.72 | CHRM1 (0.74) | DRD2CHRM1HTR1ACHRM2CHRM4 | |
| SCHEMBL5337374 | 0.71 | DRD2 (0.53) | DRD2CHRM1HTR1ACHRM2CHRM4 | |
| SCHEMBL6696545 | 0.71 | DRD2 (0.50) | DRD2HTR1ASLC6A4ADRB2 | |
| SCHEMBL19876785 | 0.71 | PTGS2 (0.50) | CYP2C9 | |
| SCHEMBL5332205 | 0.70 | DRD2 (0.52) | DRD2ACHESLC6A4HRH3 | |
| SCHEMBL4497800 | 0.70 | CHRM1 (0.77) | DRD2CHRM1HTR1ACHRM2CHRM4 | |
| SCHEMBL5345306 | 0.70 | CHRM1 (0.61) | DRD2CHRM1HTR1ACHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1278741-A1 | MUSCARINIC AGONISTS | Acadia Pharmaceuticals Inc. (US) | 2003-01-29 | — | — | EP | claimed |
| WO-2001083472-A1 | MUSCARINIC AGONISTS | ACADIA PHARMACEUTICALS, INC. (US) | 2001-11-08 | — | — | WO | claimed |
| EP-1278741-A1 | MUSCARINIC AGONISTS | Acadia Pharmaceuticals Inc. (US) | 2003-01-29 | — | — | EP | disclosed |
| WO-2001083472-A1 | MUSCARINIC AGONISTS | ACADIA PHARMACEUTICALS, INC. (US) | 2001-11-08 | — | — | WO | disclosed |