Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NOD1 | Q9Y239 | 4/20 | 0.38 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | WDR5 | P61964 | 2/20 | 0.38 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | IDE | P14735 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5763411 | 0.93 | ALDH1A1 (0.44) | ALDH1A1HTTTP53SMN1; SMN2TSHR | |
| SCHEMBL5763423 | 0.93 | ALDH1A1 (0.44) | ALDH1A1HTTTP53SMN1; SMN2TSHR | |
| SCHEMBL13053533 | 0.93 | ALDH1A1 (0.44) | ALDH1A1HTTTP53SMN1; SMN2TSHR | |
| SCHEMBL5763405 | 0.93 | ALDH1A1 (0.43) | ALDH1A1HTTTP53SMN1; SMN2TSHR | |
| SCHEMBL7012259 | 0.92 | SMN1; SMN2 (0.40) | ALDH1A1HTTTP53SMN1; SMN2TSHR | |
| SCHEMBL7233208 | 0.91 | ALDH3A1 (0.38) | ALDH1A1HTTTP53SMN1; SMN2TSHR | |
| SCHEMBL7011328 | 0.88 | ALDH1A1 (0.38) | ALDH1A1HTTTP53SMN1; SMN2TSHR | |
| SCHEMBL7010552 | 0.88 | MAPT (0.44) | ALDH1A1HTTTP53SMN1; SMN2TSHR | |
| SCHEMBL7011482 | 0.88 | ALDH1A1 (0.40) | ALDH1A1HTTTP53SMN1; SMN2TSHR | |
| SCHEMBL5763540 | 0.87 | ALDH1A1 (0.41) | ALDH1A1HTTTP53SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6559167-B1 | Prodrugs of the pyridyl methyl sulfinyl benzimidazole type proton pump inhibitor drugs have a hydrolyzable arylsulfonyl or heteroarylsulfonyl group attached to the benzimidazole nitrogen. The prodrugs of the invention hydrolyze under | REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2003-05-06 | — | — | US | claimed |
| EP-1105387-B1 | PRODRUGS OF PROTON PUMP INHIBITORS | WINSTON PHARMATEUTICALS LLC (US) | 2003-01-29 | — | — | EP | claimed |
| US-6559167-B1 | Prodrugs of the pyridyl methyl sulfinyl benzimidazole type proton pump inhibitor drugs have a hydrolyzable arylsulfonyl or heteroarylsulfonyl group attached to the benzimidazole nitrogen. The prodrugs of the invention hydrolyze under | REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2003-05-06 | — | — | US | disclosed |
| EP-1105387-B1 | PRODRUGS OF PROTON PUMP INHIBITORS | WINSTON PHARMATEUTICALS LLC (US) | 2003-01-29 | — | — | EP | disclosed |