Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | VNN1 | O95497 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | VEGFA | P15692 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7012075 | 0.91 | HDAC1 (0.42) | HDAC1HDAC6HDAC3HDAC2HDAC8 | |
| SCHEMBL7012413 | 0.83 | HDAC3 (0.46) | HDAC1HDAC6HDAC3HDAC2HDAC8 | |
| SCHEMBL7013123 | 0.81 | HDAC1 (0.46) | HDAC1HDAC6HDAC3HDAC2HDAC8 | |
| SCHEMBL7012720 | 0.80 | VNN1 (0.41) | HDAC1HDAC6HDAC3HDAC2HDAC8 | |
| SCHEMBL7014669 | 0.78 | HDAC1 (0.42) | HDAC1HDAC6HDAC3HDAC2HDAC8 | |
| SCHEMBL7016174 | 0.78 | VNN1 (0.41) | HDAC1HDAC6HDAC3HDAC2HDAC8 | |
| SCHEMBL7021991 | 0.75 | HDAC1 (0.42) | HDAC1HDAC6HDAC3HDAC2HDAC8 | |
| SCHEMBL7010809 | 0.70 | TP53 (0.48) | HDAC1HDAC6HDAC3HDAC2HDAC8 | |
| SCHEMBL7011613 | 0.68 | MAPK1 (0.43) | HDAC1HDAC6HDAC3HDAC2HDAC8 | |
| SCHEMBL7012844 | 0.68 | HDAC1 (0.47) | HDAC1HDAC6HDAC3HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733633-B1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-05-28 | — | — | EP | disclosed |
| EP-0733633-A1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-09-25 | — | — | EP | disclosed |