Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | EDNRB | P24530 | 2/20 | 0.32 |
| ▸ | EDNRA | P25101 | 2/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7010894 | 0.82 | MCL1 (0.38) | LMNAMCL1MAPTEDNRBEDNRA | |
| SCHEMBL7011111 | 0.81 | EDNRB (0.39) | MCL1MAPTEDNRBEDNRANR1H2 | |
| SCHEMBL7007654 | 0.81 | MCL1 (0.40) | MCL1MAPTEDNRBEDNRANR1H2 | |
| SCHEMBL7006390 | 0.81 | MCL1 (0.37) | LMNAMCL1MAPTEDNRBEDNRA | |
| SCHEMBL7008566 | 0.81 | GAA (0.37) | LMNAMCL1MAPTEDNRBEDNRA | |
| SCHEMBL7009283 | 0.78 | EDNRB (0.40) | LMNAMCL1MAPTEDNRBEDNRA | |
| SCHEMBL9407273 | 0.76 | MAPT (0.38) | LMNAMCL1MAPTEDNRBEDNRA | |
| SCHEMBL7009200 | 0.76 | EDNRB (0.38) | MCL1MAPTEDNRBEDNRANR1H2 | |
| SCHEMBL7302716 | 0.76 | MAPK14 (0.35) | LMNANR1H2JAK2JAK1TYK2 | |
| SCHEMBL7013471 | 0.75 | EDNRA (0.49) | EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0601386-B1 | Sulphonamides | HOFFMANN LA ROCHE (CH) | 2003-02-05 | — | — | EP | claimed |
| EP-0601386-A1 | Sulphonamides | F. HOFFMANN-LA ROCHE AG (CH) | 1994-06-15 | — | — | EP | claimed |
| EP-0601386-B1 | Sulphonamides | HOFFMANN LA ROCHE (CH) | 2003-02-05 | — | — | EP | disclosed |
| EP-0601386-A1 | Sulphonamides | F. HOFFMANN-LA ROCHE AG (CH) | 1994-06-15 | — | — | EP | disclosed |