Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN12 | Q05209 | 1/20 | 0.43 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | GLA | P06280 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7016674 | 0.93 | PTPN12 (0.47) | PTPN12PTPN22HTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL7020439 | 0.91 | PTPN12 (0.45) | PTPN12PTPN22HTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8183600 | 0.90 | PSMD14 (0.47) | PTPN12PTPN22HTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL7016750 | 0.89 | CNR1 (0.46) | PTPN12PTPN22HTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL7019806 | 0.89 | PDE4A (0.40) | HTTSMN1; SMN2ALDH1A1KDM4ELMNA | |
| SCHEMBL7017023 | 0.88 | PDE4A (0.42) | SMN1; SMN2ALDH1A1KDM4ELMNAALOX15 | |
| SCHEMBL7020085 | 0.87 | PDE4A (0.40) | ALDH1A1KDM4ELMNAALOX15USP2 | |
| SCHEMBL8177876 | 0.86 | PDE4A (0.53) | PTPN12PTPN22HTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL7009748 | 0.85 | PDE4A (0.44) | ALDH1A1KDM4ELMNAALOX15USP2 | |
| SCHEMBL7018279 | 0.84 | PDE4A (0.43) | ALDH1A1KDM4ELMNAALOX15USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934321-B1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 2003-08-06 | — | — | EP | disclosed |
| EP-0934321-A1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GmbH (DE) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998017668-A1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 1998-04-30 | — | — | WO | disclosed |