Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 4/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19732867 | 0.73 | SIGMAR1 (0.41) | SIGMAR1 | |
| SCHEMBL2171598 | 0.72 | MAPT (0.50) | MAOBSIGMAR1MAPT | |
| SCHEMBL7012615 | 0.69 | KDM4E (0.45) | MAPT | |
| SCHEMBL7016003 | 0.68 | — | — | |
| SCHEMBL13871482 | 0.64 | NPSR1 (0.42) | SIGMAR1TP53MAPT | |
| SCHEMBL10814919 | 0.64 | SIGMAR1 (0.47) | MAOBSIGMAR1MAPT | |
| SCHEMBL10506788 | 0.63 | SIGMAR1 (0.44) | MAOBSIGMAR1TP53MAPT | |
| SCHEMBL9628095 | 0.63 | DRD3 (0.41) | MAPT | |
| SCHEMBL11209054 | 0.62 | TP53 (0.72) | MAOAMAOBTP53MAPT | |
| SCHEMBL2959003 | 0.62 | BCHE (0.51) | TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1048651-B1 | NITROGEN-CONTAINING TETRACYCLIC COMPOUNDS | TAISHO PHARMACEUTICAL CO LTD (JP) | 2003-05-14 | — | — | EP | disclosed |
| US-6281355-B1 | Nitrogen-containing tetracyclic compounds | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2001-08-28 | — | — | US | disclosed |
| EP-1048651-A1 | NITROGEN-CONTAINING TETRACYCLIC COMPOUNDS | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2000-11-02 | — | — | EP | disclosed |