Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.67 |
| ▸ | CNR1 | P21554 | 8/20 | 0.52 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | DAO | P14920 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | DDO | Q99489 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinoline SCHEMBL28309176 | 0.84 | CA2 (0.50) | CA2CNR1AKR1B1MAPTALDH1A1 | |
| SCHEMBL28568569 | 0.83 | CA2 (0.71) | CA2CNR1AKR1B1BRD4KDM4E | |
| SCHEMBL329510 | 0.82 | CA2 (0.69) | CA2CNR1AKR1B1BRD4KDM4E | |
| SCHEMBL19928719 | 0.81 | CA2 (0.58) | CA2CNR1AKR1B1BRD4KDM4E | |
| SCHEMBL32681985 | 0.80 | CA2 (1.00) | CA2CNR1AKR1B1FLT3CYP2A6 | |
| SCHEMBL516901 | 0.80 | CA2 (0.67) | CA2CNR1AKR1B1BRD4KDM4E | |
| SCHEMBL29560278 | 0.80 | CA2 (0.67) | CA2CNR1AKR1B1BRD4KDM4E | |
| SCHEMBL32895 | 0.80 | CA2 (1.00) | CA2CNR1AKR1B1FLT3CYP2A6 | |
| SCHEMBL517161 | 0.80 | CA2 (0.67) | CA2CNR1AKR1B1BRD4KDM4E | |
| SCHEMBL5610313 | 0.80 | CA2 (0.67) | CA2CNR1AKR1B1BRD4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112538034-B | Synthetic method of florfenicol | 山东国邦药业有限公司 | 2023-01-31 | — | — | CN | disclosed |
| CN-112538034-A | Synthetic method of florfenicol | 山东国邦药业有限公司 | 2021-03-23 | — | — | CN | disclosed |
| WO-2005065688-A1 | NEW DERIVATIVES OF 6-4{4-[1H-INDOLE-2-SULPHONYL)-PIPERAZIN-1-CARBONYL-PHENYL]}PYRADIZIN-3-ONE | ASTRAZENECA AB (SE) | 2005-07-21 | — | — | WO | disclosed |
| EP-1268421-A2 | PHENYL-SUBSTITUTED INDOLES AS HISTAMINE H3-RECEPTOR ANTAGONISTS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001074773-A2 | PHENYL-SUBSTITUTED INDOLES AS HISTAMINE H3-RECEPTOR ANTAGONISTS | ORTHO MCNEIL PHARMACEUTICAL, INC. (US) | 2001-10-11 | — | — | WO | disclosed |
| US-5436264-A | Adrenergic blocking agents for vasoconstriction and hypotensive agents | SYNTEX (U.S.A.) INC. (US) | 1995-07-25 | — | — | US | disclosed |
| EP-0279263-B1 | INDOLE, BENZOFURAN, BENZOTHIOPHENE CONTAINING LIPOXYGENASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1993-08-04 | — | — | EP | disclosed |
| US-4873259-A | Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1989-10-10 | — | — | US | disclosed |
| EP-0279263-A2 | Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1988-08-24 | — | — | EP | disclosed |