Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6353312 | 0.81 | SMN1; SMN2 (0.53) | ALDH1A1CYP1A2KDM4EHPGDNPC1 | |
| SCHEMBL6354319 | 0.78 | SMN1; SMN2 (0.50) | ADORA3ADORA2AADORA1ALDH1A1CYP1A2 | |
| SCHEMBL31040054 | 0.76 | ADORA3 (0.41) | ADORA3ADORA2AADORA1ALDH1A1CYP1A2 | |
| SCHEMBL4169299 | 0.76 | SMN1; SMN2 (0.44) | ALDH1A1CYP1A2KDM4EHPGDRAB9A | |
| SCHEMBL29772638 | 0.74 | SMN1; SMN2 (0.39) | ADORA3ADORA2AADORA1ALDH1A1CYP1A2 | |
| SCHEMBL31065500 | 0.74 | MAPT (0.40) | ADORA3ADORA2AADORA1ALDH1A1CYP1A2 | |
| SCHEMBL7013061 | 0.74 | CYP3A4 (0.51) | CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL13090307 | 0.71 | POLB (0.40) | ALDH1A1CYP1A2KDM4EHPGDPOLB | |
| SCHEMBL2681486 | 0.71 | GABRP (0.43) | ADORA3ALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL5634670 | 0.69 | SMN1; SMN2 (0.59) | ADORA3ADORA2AADORA1ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6613775-B1 | 8-(2,6-dimethylbenzylamino)-2-hydroxymethyl-3-methylimidazo(1, 2-a)pyridine used as antisecretory agents for prophylaxis of gastrointestinal disorders such as ulcers | ASTRAZENECA AB (SE) | 2003-09-02 | — | — | US | disclosed |
| EP-1105390-B1 | Imidazo[1,2-a]pyridine derivatives for the treatment of gastrointestinal diseases | ASTRAZENECA AB (SE) | 2003-06-04 | — | — | EP | disclosed |