Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 11/20 | 0.41 |
| ▸ | THRB | P10828 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CMA1 | P23946 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5957762 | 0.93 | TRPA1 (0.48) | TRPA1THRBMAPTALDH1A1L3MBTL1 | |
| SCHEMBL5957317 | 0.91 | TRPA1 (0.41) | TRPA1THRBMAPTALDH1A1L3MBTL1 | |
| SCHEMBL5957855 | 0.90 | TRPA1 (0.42) | TRPA1THRBMAPTALDH1A1L3MBTL1 | |
| SCHEMBL5957416 | 0.90 | TRPA1 (0.40) | TRPA1THRBMAPTALDH1A1L3MBTL1 | |
| SCHEMBL5957381 | 0.89 | TRPA1 (0.45) | TRPA1THRBMAPTLMNATP53 | |
| SCHEMBL5957451 | 0.89 | TRPA1 (0.45) | TRPA1 | |
| SCHEMBL5957508 | 0.88 | TRPA1 (0.39) | TRPA1THRBMAPTALDH1A1L3MBTL1 | |
| SCHEMBL5957619 | 0.87 | TRPA1 (0.39) | TRPA1THRBMAPTALDH1A1L3MBTL1 | |
| SCHEMBL5957812 | 0.85 | TRPA1 (0.44) | TRPA1THRBMAPTLMNA | |
| SCHEMBL5957672 | 0.84 | CXCR3 (0.43) | TRPA1THRBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362054-A1 | BICYCLIC PYRIMIDINE MATRIX METALLOPROTEINASE INHIBITORS | Warner-Lambert Company LLC (US) | 2003-11-19 | — | — | EP | claimed |
| WO-2002064599-A1 | BICYCLIC PYRIMIDINE MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-08-22 | — | — | WO | claimed |